ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2020
Microparticles profiling in trauma patients: high level of microparticles induce activation of platelets in vitro.
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 16 citations in OpenAlex.
- From platelets to particles: Optimizing extracellular vesicle isolation in a National Blood Centre.Vox sanguinis · 2026Article
- Hemostatic abnormalities after trauma resuscitation: challenges and strategies in caring for the critically injured patient.Annals of intensive care · 2025Review
- Histone-driven hypercoagulation contributes to the lethal triad of acute trauma-induced coagulopathy.Scientific reports · 2025Article
- Exploration of potential biomarkers and therapeutic targets for trauma-related acute kidney injury.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2024Review
- Extracellular vesicles epitopes as potential biomarker candidates in patients with traumatic spinal cord injury.Frontiers in immunology · 2024Article
- "Importance of catecholamine signaling in the development of platelet exhaustion after traumatic injury": Reply.Journal of thrombosis and haemostasis : JTH · 2022Article
- Importance of catecholamine signaling in the development of platelet exhaustion after traumatic injury.Journal of thrombosis and haemostasis : JTH · 2022Article
- The emerging therapeutic potential of extracellular vesicles in trauma.Journal of leukocyte biology · 2022Review
- Plasmatic and cell-based enhancement by microparticles originated from platelets and endothelial cells under simulated in vitro conditions of a dilutional coagulopathy.Scandinavian journal of trauma, resuscitation and emergency medicine · 2021Article
- Focus on chest trauma: implications from clinical and experimental studies.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Article
- Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTrauma-induced coagulopathy (TIC) is recognised as an own clinical entity which includes all components of haemostasis following rapidly tissue injury, hypoperfusion and shock. Microparticles (MP) are known to be released in large quantities from different cell types after trauma. The present study aimed to perform a phenotypic MP profiling after major trauma and to elucidate potential procoagulative function of MP under simulated conditions of lethal triad.
methodsFor MP isolation, 20 trauma patients (median ISS 24) were included. To produce a Standard MP Phenotype Profile after trauma, samples were pooled, extracted and concentrated by using an ultracentrifuge protocol. Specific cell surface markers were measured by flow cytometry. Our Standard MP Phenotype Profile was subsequently added in high and low concentration to an in vitro lethal triad assay, simulating coagulopathy via induced hypothermia, dilution and acidosis. A comprehensive analysis of coagulation function was performed.
resultsWithin our Standard MP Phenotype Profile, PDMP (56%) were found as predominant phenotype followed by EDMP (33%) and MDMP (11%). EDMP characterized by CD144, CD62E and Annexin were determined most frequently but also EDMP expressing CD62P. In addition, tissue factor (TF) was expressed on all MP entities (EDMP 63%, PDMP 30%, MDMP 7%). Within our lethal triad simulation assay, the addition of low and high concentrated MP did not cause any significant alteration in standard coagulation assays, coagulation initiation, clot kinetics or stability. Addition of high concentrated MP increased platelet function and P-selectin expression significantly.
conclusionOur data confirm the assumption that there is a characteristic MP phenotype pattern in trauma, which may alter haemostatic capacity at least in part mediated via augmenting in primary haemostasis resulting in an improved contribution of platelets to clot formation. There are indications that expression of selectins on MP surface is involved in this activation process, but this pathway needs to be investigated in more detail.
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