ArticleJournal of physiology and biochemistry2019
HULC functions as an oncogene in ovarian carcinoma cells by negatively modulating miR-125a-3p.
Article in Journal of physiology and biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Review
- CircRNA ITCH: Insight Into Its Role and Clinical Application Prospect in Tumor and Non-Tumor Diseases.Frontiers in genetics · 2022Review
- Editorial Expression of Concern: HULC functions as an oncogene in ovarian carcinoma cells by negatively modulating miR-125a-3p.Journal of physiology and biochemistry · 2021Article
- Quantitative proteomics analysis of glioblastoma cell lines after lncRNA HULC silencing.Scientific reports · 2021Article
- CircRNA ARFGEF1 functions as a ceRNA to promote oncogenic KSHV-encoded viral interferon regulatory factor induction of cell invasion and angiogenesis by upregulating glutaredoxin 3.PLoS pathogens · 2021Article
- Long noncoding RNA HULC contributes to paclitaxel resistance in ovarian cancer via miR-137/ITGB8 axis.Open life sciences · 2021Article
- CircularRNA circPARP4 promotes glioblastoma progression through sponging miR-125a-5p and regulating FUT4.American journal of cancer research · 2021Article
- Potential role of lncRNA HULC/miR‑128‑3p/RAC1 axis in the inflammatory response during LPS‑induced sepsis in HMEC‑1 cells.Molecular medicine reports · 2020Article
- LncRNAs in Ovarian Cancer Progression, Metastasis, and Main Pathways: ceRNA and Alternative Mechanisms.International journal of molecular sciences · 2020Review
- LncRNA HULC shRNA disinhibits miR-377-5p to suppress the growth and invasion of hepatocellular carcinomaAnnals of translational medicine · 2020Article
- LPS promotes the progression of sepsis by activation of lncRNA HULC/miR-204-5p/TRPM7 network in HUVECs.Bioscience reports · 2020Article
- Genome-wide identification of a competing endogenous RNA network in cholangiocarcinoma.Journal of cellular biochemistry · 2019Article
Corrections and comments
- Retraction · 2022-03-01Falsification/Fabrication of Data · Investigation by Journal/Publisher · Investigation by Third Party · Paper Mill · Unreliable Data · Upgrade/Update of Prior Notice(s) · · see also: https://pubpeer.com/publications/B7E2DAA7D7DEE6442551B72239DC0A
- Expression of concern · 2020-09-30Concerns/Issues about Data · Concerns/Issues about Image · Investigation by Journal/Publisher · · https://pubpeer.com/publications/B7E2DAA7D7DEE6442551B72239DC0A
- Expression of concern · 2021-03-19Author Unresponsive · Concerns/Issues about Data · Concerns/Issues about Image · Investigation by Third Party · Original Data and/or Images not Provided and/or not Available · Paper Mill · Updated to Retraction · Upgrade/Update of Prior Notice(s) · · https://pubpeer.com/publications/B7E2DAA7D7DEE6442551B72239DC0A
- Expression of concern
- Retracted
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aberrant expression of highly upregulated in liver cancer (HULC) has been reported to participate in ovarian cancer development. A recent research has revealed that HULC-modulated microRNAs (miRNAs) in tumorigenesis. To confirm the functions of HULC on tumorigenesis of ovarian, we explored the effects of HULC expression on ovarian cancer cell development, as well as the underlying mechanism. We transfected SKOV3 cells with pEX-HULC, sh-HULC, and miR-125a-3p mimic as well as their corresponding negative controls (pEX-3, sh-NC, and NC) to alter the expression of HULC and miR-125a-3p, which were analyzed by quantitative reverse transcription PCR (qRT-PCR). Expression of proteins associated with cell cycle, apoptosis, and signaling pathways was determined by Western blot assay. The proliferation, apoptosis, migration, and invasion were explored by bromodeoxyuridine (BrdU) incorporation assay, Annexin V-fluorescein isothiocyanate (FITC)/propidium iodide (PI) method, and transwell migration and invasion assays, respectively. HULC overexpression promoted proliferation, migration, and invasion, while inhibited apoptosis of SKOV3 cells. In addition, HULC negatively regulated the expression of miR-125a-3p. Besides, miR-125a-3p mimic reversed the effects of HULC on proliferation, migration, and invasion as well as apoptosis of SKOV3 cells. Moreover, we found that HULC enhanced phosphorylated expression of regulatory factors in phosphatidylinositol 3 kinase/protein kinase B/mammalian targets of rapamycin (PI3K/AKT/mTOR) signaling pathway by downregulating expression of miR-125a-3p. Overexpression of HULC promoted ovarian carcinoma development by activating PI3K/AKT/mTOR signaling pathway via downregulating miR-125a-3p.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.