Evidence map›Paper›PMID 30863900›Full record

ArticleThe Journal of membrane biology2019

Photolithographic Fabrication of Micro Apertures in Dry Film Polymer Sheets for Channel Recordings in Planar Lipid Bilayers.

Mario El Khoury, Tobias Winterstein, Wadim Weber, Viktor Stein, Helmut F Schlaak, Gerhard Thiel

Open access · hybridAbstract read
In one paragraph

Article in The Journal of membrane biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mario El KhouryDepartment of Electrical Engineering and Information Technology, Institute of Electromechanical Design, Microtechnology and Electromechanical Systems, TU Darmstadt, Darmstadt, Germany.
Tobias WintersteinMembranbiophysik, Department of Biology, TU Darmstadt, Schnitspahnstrasse 3, 64287, Darmstadt, Germany.
Wadim WeberProtein Engineering, Department of Biology, TU Darmstadt, Darmstadt, Germany.
Viktor SteinProtein Engineering, Department of Biology, TU Darmstadt, Darmstadt, Germany.
Helmut F SchlaakDepartment of Electrical Engineering and Information Technology, Institute of Electromechanical Design, Microtechnology and Electromechanical Systems, TU Darmstadt, Darmstadt, Germany.
Gerhard ThielMembranbiophysik, Department of Biology, TU Darmstadt, Schnitspahnstrasse 3, 64287, Darmstadt, Germany. thiel@bio.tu-darmstadt.de.ORCID 0000-0002-2335-1351
Technische Universität Darmstadt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Planar lipid bilayers constitute a versatile method for measuring the activity of protein channels and pores on a single molecule level. Ongoing efforts attempt to tailor this method for detecting biomedically relevant target analytes or for high-throughput screening of drugs. To improve the mechanical stability of bilayer recordings, we use a thin-film epoxy resist ADEX as septum in free-standing vertical bilayers. Defined apertures with diameters between 30 µm and 100 µm were micro-fabricated by photolithography. The performance of these septa was tested by functional reconstitution of the K

Indexed as

Electric CapacitanceEpoxy ResinsIon Channel GatingLipid BilayersMicrotechnologyPhotochemical ProcessesPolytetrafluoroethylenePorosityPotassium ChannelsSignal-To-Noise RatioSingle Molecule ImagingEpoxy ResinsLipid BilayersPolytetrafluoroethylenePotassium ChannelsIon channel recordingPhotolithographyPlanar lipid bilayer

Identifiers

PMID30863900
PMCPMC6556160
OpenAlexW2922276353

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.