Evidence map›Paper›PMID 30863894›Full record

Trial reportEuropean journal of nutrition2020

Consumption of a soy drink has no effect on cognitive function but may alleviate vasomotor symptoms in post-menopausal women; a randomised trial.

Orlaith N Furlong, Heather J Parr, Stephanie J Hodge, Mary M Slevin, Ellen E Simpson, Emeir M McSorley, Jacqueline M McCormack, Pamela J Magee

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Bioactive Compounds for Customized Brain Health: What Are We and Where Should We Be Heading?International journal of environmental research and public health · 2023
    Review
  6. Review
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Orlaith N FurlongNutrition Innovation Centre for Food and Health, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK.ORCID http://orcid.org/0000-0003-3825-2775
Heather J ParrNutrition Innovation Centre for Food and Health, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK.ORCID http://orcid.org/0000-0003-3104-6100
Stephanie J HodgeNutrition Innovation Centre for Food and Health, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK.ORCID http://orcid.org/0000-0001-7949-0660
Mary M SlevinNutrition Innovation Centre for Food and Health, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK.ORCID http://orcid.org/0000-0003-0977-8209
Ellen E SimpsonPsychology Research Institute, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK.ORCID http://orcid.org/0000-0003-4572-8436
Emeir M McSorleyNutrition Innovation Centre for Food and Health, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK.ORCID http://orcid.org/0000-0003-1861-3991
Jacqueline M McCormackNutrition Innovation Centre for Food and Health, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK.ORCID http://orcid.org/0000-0002-6444-9072
Pamela J MageeNutrition Innovation Centre for Food and Health, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK. pj.magee@ulster.ac.uk.ORCID http://orcid.org/0000-0002-0479-3314
University of Ulster · GBUniversity of East Anglia · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCognitive decline is commonly reported during the menopausal transition, with memory and attention being particularly affected. The aim of this study was to investigate the effects of a commercially available soy drink on cognitive function and menopausal symptoms in post-menopausal women.

methods101 post-menopausal women, aged 44-63 years, were randomly assigned to consume a volume of soy drink providing a low (10 mg/day; control group), medium (35 mg/day), or high (60 mg/day) dose of isoflavones for 12 weeks. Cognitive function (spatial working memory, spatial span, pattern recognition memory, 5-choice reaction time, and match to sample visual search) was assessed using CANTAB pre- and post-the 12 week intervention. Menopausal symptoms were assessed using Greene's Climacteric Scale.

resultsNo significant differences were observed between the groups for any of the cognitive function outcomes measured. Soy drink consumption had no effect on menopausal symptoms overall; however, when women were stratified according to the severity of vasomotor symptoms (VMS) at baseline, women with more severe symptoms at baseline in the medium group had a significant reduction (P = 0.001) in VMS post-intervention (mean change from baseline score: - 2.15 ± 1.73) in comparison to those with less severe VMS (mean change from baseline score: 0.06 ± 1.21).

conclusionsSoy drink consumption had no effect on cognitive function in post-menopausal women. Consumption of ~ 350 ml/day (35 mg IFs) for 12 weeks significantly reduced VMS in those with more severe symptoms at baseline. This finding is clinically relevant as soy drinks may provide an alternative, natural, treatment for alleviating VMS, highly prevalent among western women.

Indexed as

AdultCognitionFemaleHumansIsoflavonesMemoryMiddle AgedPostmenopauseReaction TimeSeverity of Illness IndexSoy MilkVasomotor SystemIsoflavonesCANTABEquolHot flashHot flushIsoflavonesMenopausal symptoms

Identifiers

PMID30863894
PMCPMC7058672
OpenAlexW2921750593

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.