ArticleJournal of molecular evolution2019
Visualization of Genetic Drift Processes Using the Conserved Collagen 1α1 GXY Domain.
Article in Journal of molecular evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Identification of collagen 1α3 in teleost fish species and typical collision induced internal fragmentations.Food chemistry: X · 2022Article
- Article
- The quest for a generic bird target to detect the presence of bird in food products and considerations for paleoprotein analysis.PloS one · 2022Article
- Non-targeted and targeted analysis of collagen hydrolysates during the course of digestion and absorption.Analytical and bioanalytical chemistry · 2020Article
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1 author at 1 institution in 1 country.
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Abstract
Speciation proceeds by the accumulation of DNA differences in time. The genetic code changes as a result of genetic drift and by selective pressure. In variable domains, exposure to high selective pressure obscures the view on background mutations. Therefore, we characterized and visualized background mutations using the highly conserved collagen 1α1 GXY domain. Typical change routes were identified and the data set showed several indications that changes in the collagen 1α1 GXY domain have taken place randomly within a functionally restricted space. The types of nucleotide and codon group differences are similar across the vertebrate subphylum and gradually become less functionally neutral with increasing distance between species, which offers the opportunity for rapid visualization of evolutionary relations using a single domain. It was concluded that the findings and approach of the study could be important for analytical method development in authenticity research, especially when conserved domains are targeted.
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