ArticlePsychopharmacology2019
Avoid-approach conflict behaviors differentially affected by anxiolytics: implications for a computational model of risky decision-making.
Article in Psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Dopamine dynamics as a regulatory mechanism for shifting between defensive and reward-seeking behaviors.Communications biology · 2026Article
- Diazepam selectively biases approach during threat-reward conflict while sparing reactive avoidance.Psychopharmacology · 2026Article
- Hippocampal representations differentiate reactive and anticipatory responses during foraging under threat.bioRxiv : the preprint server for biology · 2026Article
- Manipulation of interoceptive signaling biases decision making in rhesus macaques.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dorsal hippocampus represents locations to avoid as well as locations to approach during approach-avoidance conflict.PLoS biology · 2025Article
- Interoceptive Signals Bias Decision Making in Rhesus Macaques.bioRxiv : the preprint server for biology · 2024Article
- Ventral Pallidum and Amygdala Cooperate to Restrain Reward Approach under Threat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Dorsal hippocampus represents locations to avoid as well as locations to approach during approach-avoidance conflict.bioRxiv : the preprint server for biology · 2024Article
- Bed nucleus of the stria terminalis GABA neurons are necessary for changes in foraging behaviour following an innate threat.The European journal of neuroscience · 2023Article
- Quantifying aberrant approach-avoidance conflict in psychopathology: A review of computational approaches.Neuroscience and biobehavioral reviews · 2023Review
- Bed Nucleus of the Stria Terminalis GABA neurons are necessary for changes in foraging behavior following an innate threat.bioRxiv : the preprint server for biology · 2023Article
- Chronic alcohol consumption alters home-cage behaviors and responses to ethologically relevant predator tasks in mice.Alcoholism, clinical and experimental research · 2022Article
- A Corticothalamic Circuit Trades off Speed for Safety during Decision-Making under Motivational Conflict.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Multiplexed action-outcome representation by striatal striosome-matrix compartments detected with a mouse cost-benefit foraging task.Nature communications · 2022Article
- Computational validity: using computation to translate behaviours across species.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Potential roles of the rodent medial prefrontal cortex in conflict resolution between multiple decision-making systems.International review of neurobiology · 2021Review
- Conflict Test Battery for Studying the Act of Facing Threats in Pursuit of Rewards.Frontiers in neuroscience · 2021Article
- Proceedings of the 2019 annual meeting of the Fetal Alcohol Spectrum Disorders Study Group.Alcohol (Fayetteville, N.Y.) · 2020Article
- From Isolated Emotional Memories to Their Competition During Conflict.Frontiers in behavioral neuroscience · 2020Article
- Editorial: bridging the gap with computational and translational psychopharmacology.Psychopharmacology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Whether fear or anxiety is expressed is thought to depend on an animal's proximity to threat. In general, fear is elicited when threat is proximal, while anxiety is a response to threat that is distal and uncertain. This threat gradient model suggests that fear and anxiety involve non-overlapping neural circuitry, yet few behavioral paradigms exist that elicit both states. We studied avoid-approach conflict in rats that were behaving in a predator-inhabited foraging arena task that involved tangible threat and reward incentives. In the task, rats exhibited a variety of both fearful and anxious behaviors corresponding to proximal and distal threat, respectively. We then administered ethanol or diazepam to the rats in order to study how anxiolytics affected these fear and anxiety behaviors. We discovered that both ethanol and diazepam attenuated proximal-threat fear-like behaviors. Furthermore, we found that diazepam, but not ethanol, increased distal-threat anxiety-like behavior but also made rats less risk-averse. Finally, we describe how decisional conflict can be modeled as a partially observable Markov decision process and characterize a potential relationship between anxious behavior, diazepam's ability to suppress hippocampal theta oscillations, and hippocampal representations of the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.