Evidence map›Paper›PMID 30863412›Full record

ArticleFrontiers in immunology2019

Reversal of New Onset Type 1 Diabetes by Oral

Jacques C Mbongue, Jeffrey Rawson, Pablo A Garcia, Nelson Gonzalez, Jacob Cobb, Fouad Kandeel, Kevin Ferreri, Mohamed I Husseiny

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Vaccines · 2025
    Review
  2. Article
  3. Review
  4. GαJournal of the Endocrine Society · 2024
    Article
  5. Article
  6. Article
  7. From bench to bedside: targeting lymphocyte activation gene 3 as a therapeutic strategy for autoimmune diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review
  8. Engineering live attenuated vaccines: Old dogs learning new tricks.Journal of translational autoimmunity · 2023
    Review
  9. Article
  10. Review
  11. Review
  12. OralFrontiers in immunology · 2021
    Article
  13. Review
  14. Article
  15. IL-27 Regulated CD4Frontiers in immunology · 2020
    Article
  16. Tracking of an OralFrontiers in immunology · 2020
    Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jacques C MbongueDepartment of Translational Research & Cellular Therapeutics, Diabetes & Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA, United States.
Jeffrey RawsonDepartment of Translational Research & Cellular Therapeutics, Diabetes & Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA, United States.
Pablo A GarciaDepartment of Translational Research & Cellular Therapeutics, Diabetes & Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA, United States.
Nelson GonzalezDepartment of Translational Research & Cellular Therapeutics, Diabetes & Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA, United States.
Jacob CobbDepartment of Translational Research & Cellular Therapeutics, Diabetes & Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA, United States.
Fouad KandeelDepartment of Translational Research & Cellular Therapeutics, Diabetes & Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA, United States.
Kevin FerreriDepartment of Translational Research & Cellular Therapeutics, Diabetes & Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA, United States.
Mohamed I HusseinyDepartment of Translational Research & Cellular Therapeutics, Diabetes & Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA, United States.
City of Hope · USBeckman Research Institute

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune diseases such as type 1 diabetes (T1D) involve the loss of regulatory mechanisms resulting in increased tissue-specific cytotoxicity. The result is destruction of pancreatic insulin-producing β-cells and loss of glucose homeostasis. We are developing a novel oral vaccine using live attenuated

Indexed as

Administration, OralAdoptive TransferAnimalsAntibodies, MonoclonalAutoantigensCD3 ComplexCombined Modality TherapyDiabetes Mellitus, Type 1Immune ToleranceInsulinInterleukin-10MiceMice, Inbred NODProtein PrecursorsSalmonellaT-Lymphocytes, RegulatoryAntibodies, MonoclonalAutoantigensCD3 ComplexInsulinInterleukin-10preproinsulinProtein PrecursorsTransforming Growth Factor beta1Vaccines, Attenuatedimmunomodulatorsimmunotherapyoral vaccineSalmonellaTr1-cellsTreg-cellstype 1 diabetes

Identifiers

PMID30863412
PMCPMC6400227
OpenAlexW2915776864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.