Evidence map›Paper›PMID 30863359›Full record

ArticleFrontiers in neurology2019

Dietary Vitamin E as a Protective Factor for Parkinson's Disease: Clinical and Experimental Evidence.

Tommaso Schirinzi, Giuseppina Martella, Paola Imbriani, Giulia Di Lazzaro, Donatella Franco, Vito Luigi Colona, Mohammad Alwardat, Paola Sinibaldi Salimei, Nicola Biagio Mercuri, Mariangela Pierantozzi and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.

  1. Pooled it
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  15. In defence of ferroptosis.Signal transduction and targeted therapy · 2025
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Tommaso SchirinziDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Giuseppina MartellaDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Paola ImbrianiDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Giulia Di LazzaroDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Donatella FrancoDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Vito Luigi ColonaDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Mohammad AlwardatDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Paola Sinibaldi SalimeiDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Nicola Biagio MercuriDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Mariangela PierantozziDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Antonio PisaniDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
University of Rome Tor Vergata · ITFondazione Santa Lucia · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effective disease-modifying treatments are an urgent need for Parkinson's disease (PD). A putative successful strategy is to counteract oxidative stress, not only with synthetic compounds, but also with natural agents or dietary choices. Vitamin E, in particular, is a powerful antioxidant, commonly found in vegetables and other components of the diet. In this work, we performed a questionnaire based case-control study on 100 PD patients and 100 healthy controls. The analysis showed that a higher dietary intake of Vitamin E was inversely associated with PD occurrence independently from age and gender (OR = 1.022; 95% CI = 0.999-1.045;

Indexed as

antioxidantdietneuroprotectionParkinson's diseasePINK1protective factorssynaptic plasticityVitamin E

Identifiers

PMID30863359
PMCPMC6399121
OpenAlexW2916850271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.