Evidence map›Paper›PMID 30863326›Full record

ArticleFrontiers in psychiatry2019

Sex-Specific Involvement of Estrogen Receptors in Behavioral Responses to Stress and Psychomotor Activation.

Polymnia Georgiou, Panos Zanos, Carleigh E Jenne, Todd D Gould

Open access · goldAbstract read
In one paragraph

Article in Frontiers in psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Observational
  5. Review
  6. Article
  7. Sex Differences in Psychosis: Focus on Animal Models.Current topics in behavioral neurosciences · 2023
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Expression ofPrzeglad menopauzalny = Menopause review · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Polymnia GeorgiouDepartment of Psychiatry, School of Medicine, University of Maryland, Baltimore, MD, United States.
Panos ZanosDepartment of Psychiatry, School of Medicine, University of Maryland, Baltimore, MD, United States.
Carleigh E JenneDepartment of Psychiatry, School of Medicine, University of Maryland, Baltimore, MD, United States.
Todd D GouldDepartment of Psychiatry, School of Medicine, University of Maryland, Baltimore, MD, United States.
University of Maryland, Baltimore · US

Funding

Role of Brain Estradiol in the Treatment of Male Depression and AnxietyR21MH100700 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI GOULD, TODD D, PROKAI, LASZLO · 2013 to 2014
$429k
NIMH NIH HHS R21 MH100700
6 · The paper itself

Abstract

Fluctuating hormone levels, such as estradiol might underlie the difference in the prevalence of psychiatric disorders observed in women vs. men. Estradiol exert its effects primarily through binding on the two classical estrogen receptor subtypes, alpha (ERα) and beta (ERβ). Both receptors have been suggested to a have role in the development of psychiatric disorders, however, most of the current literature is limited to their role in females. We investigated the role of estrogen receptors on cognition (novel-object recognition), anxiety (open-field test, elevated-plus maze, and light/dark box), stress-responsive behaviors (forced-swim test, learned helplessness following inescapable shock, and sucrose preference), pre-pulse inhibition (PPI) and amphetamine-induced hyperlocomotion in both male and female mice either lacking the ERα or ERβ receptor. We found that female

Indexed as

amphetaminedepressive-like behaviorsestrogen receptor alphaestrogen receptor betamood disorderspsychomotor activationsex differencesstress

Identifiers

PMID30863326
PMCPMC6399411
OpenAlexW2917973162

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.