SynthesisFrontiers in physiology2019
Long-Term Aerobic Exercise Improves Vascular Function Into Old Age: A Systematic Review, Meta-Analysis and Meta Regression of Observational and Interventional Studies.
Synthesis in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 6 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Impact of Aerobic Exercise on Endothelial Function and Other Cardiovascular Disease Markers in Health and Disease: A Systematic Review and Meta-analysis with Meta-regression of Randomized Controlled Trials.Sports medicine - open · 2026Pooled it
- Comparative effectiveness of various exercise modalities on arterial stiffness and endothelial function in older adults: a systematic review and network meta-analysis of randomised controlled trials.Frontiers in cardiovascular medicine · 2026Pooled it
- Comparing Aerobic Interval Training with Other Forms of Physical Exercise for Brachial Artery Endothelial Function Improvement: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials.Sports medicine - open · 2025Pooled it
- Impacts of Physical Inactivity Models on Endothelial Function: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2025Pooled it
- Efficacy of exercise training for improving vascular dysfunction in people with cancer: a systematic review with meta-analyses.Journal of cancer survivorship : research and practice · 2024Pooled it
- Pooled it
- The impact of age and exercise training on endothelial-mediated mechanisms of vasodilation during passive leg movement in males.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Day-to-Day Reproducibility of Arterial Stiffness Following a Bout of Resistance Exercise in Healthy Young Females: A Reliability Study.Health science reports · 2026Article
- Reprogramming the Mitochondrion in Atherosclerosis: Targets for Vascular Protection.Antioxidants (Basel, Switzerland) · 2025Review
- A 12-week cycling program improves glucose homeostasis, lipid profile, and body composition in women with insulin resistance: a pilot study.Nagoya journal of medical science · 2025Article
- Effects of aerobic training on brachial artery flow-mediated dilation in healthy adults: a meta-analysis of inter-individual response differences in randomized controlled trials.BMC sports science, medicine & rehabilitation · 2025Article
- Physical activity interventions implemented for older people in Sub-Saharan Africa: a scoping review.BMJ open · 2024Article
- Training the Vessels: Molecular and Clinical Effects of Exercise on Vascular Health-A Narrative Review.Cells · 2023Review
- Effects of physical activity breaks during prolonged sitting on vascular and executive function-A randomised cross-over trial.Journal of Taibah University Medical Sciences · 2023Article
- Habitual exercise influences carotid artery strain and strain rate, but not cognitive function in healthy middle-aged females.European journal of applied physiology · 2023Article
- VascuFit: vascular effects of non-linear periodized exercise training in sedentary adults with elevated cardiovascular risk - protocol for a randomized controlled trial.BMC cardiovascular disorders · 2022Article
- A Personalized Smartphone-Delivered Just-in-time Adaptive Intervention (JitaBug) to Increase Physical Activity in Older Adults: Mixed Methods Feasibility Study.JMIR formative research · 2022Article
- Arterial stiffness acute changes following aerobic exercise in males with and without hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- The effect of acute aerobic exercise on arterial stiffness in individuals with different body fat percentages: A cross-sectional study.Frontiers in cardiovascular medicine · 2022Article
- Editorial: ICT-based training intervention for healthy aging: ITIHA.Frontiers in physiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is an emerging body of literature relating to the effectiveness of frequent aerobic exercise as a prophylactic for age-associated dysfunction of large arteries, yet systematic evaluation and precise estimate of this effect is unknown. We conducted a systematic review and meta-analysis of controlled studies examining flow mediated dilatation (FMD) of athletic older persons and otherwise healthy sedentary counterparts to (i) compare FMD as a determinant of endothelial function between athletes and sedentary individuals and, (ii) summarize the effect of exercise training on FMD in studies of sedentary aging persons. Studies were identified from systematic search of major electronic databases from inception to January 2018. Study quality was assessed before conducting a random effects meta-analysis to calculate a pooled ES (mean difference) with 95% CI's. Thirteen studies [4 interventional (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.