ArticleFrontiers in behavioral neuroscience2019
Testosterone Reduces Fear and Causes Drastic Hypomethylation of Arginine Vasopressin Promoter in Medial Extended Amygdala of Male Mice.
Article in Frontiers in behavioral neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Intravenous kisspeptin 112-121 bolus does not acutely impact circulating vasopressin in humans.Journal of neuroendocrinology · 2026Article
- Exploring behavioral outcomes of gonadectomy in pets: a need for personalized approaches.Animal reproduction · 2026Review
- Dihydrotestosterone regulation of stress-related behaviors in mice exposed to subchronic variable stress.Psychoneuroendocrinology · 2025Article
- Dog Neuter, Yes or No? A Summary of the Motivations, Benefits, and Harms, with Special Emphasis on the Behavioral Aspect.Animals : an open access journal from MDPI · 2025Review
- Article
- The risks of unconcern: low sensitivity to threat can have unfortunate consequences.Frontiers in psychology · 2024Article
- Defensive responses: behaviour, the brain and the body.Nature reviews. Neuroscience · 2023Review
- Sex differences in androgen receptor, estrogen receptor alpha, and c-Fos co-expression with corticotropin releasing factor expressing neurons in restrained adult mice.Hormones and behavior · 2023Article
- Article
- Intra-pituitary follicle-stimulating hormone signaling regulates hepatic lipid metabolism in mice.Nature communications · 2023Article
- Modulation of social behavior by distinct vasopressin sources.Frontiers in endocrinology · 2023Review
- Effects of prenatal bisphenol S and bisphenol F exposure on behavior of offspring mice.Animal cells and systems · 2023Article
- Androgen Regulation of Corticotropin Releasing Factor Receptor 1 in the Mouse Brain.Neuroscience · 2022Article
- Associations betweenInternational journal for parasitology. Parasites and wildlife · 2022Article
- Impact of Plant-Based Foods and Nutraceuticals onFrontiers in nutrition · 2022Review
- Sex-specific maternal programming of corticosteroid-binding globulin by predator odour.Proceedings. Biological sciences · 2021Article
- Arginine vasopressin in the medial amygdala causes greater post-stress recruitment of hypothalamic vasopressin neurons.Molecular brain · 2021Article
- Distribution of Vasopressin and Oxytocin Neurons in the Basal Forebrain and Midbrain of Spiny Mice (Acomys cahirinus).Neuroscience · 2021Article
- Behavioral biology of Toxoplasma gondii infection.Parasites & vectors · 2021Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Testosterone reduces anxiety-like behaviors in rodents and increases exploration of anxiogenic parts of the environment. Effects of testosterone on innate defensive behaviors remain understudied. Here, we demonstrate that exogenous testosterone reduces aversion to cat odor in male mice. This is reflected as increased exploration of area containing cat urine when castrated male mice are supplied with exogenous testosterone. We also report that exogenous testosterone leads to DNA hypomethylation of arginine vasopressin (AVP) promoter in posterodorsal medial amygdala (MePD) and medial bed nucleus of stria terminalis (BNST). Our observations suggest that testosterone acting on AVP system within extended medial amygdala might regulate defensive behaviors in mice.
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Registered trials
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