ArticleCancer management and research2019
p53-positive expression in dysplastic surgical margins is a predictor of tumor recurrence in patients with early oral squamous cell carcinoma.
Article in Cancer management and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Expression of p53, Ki-67, sox-2, oct-4, and NANOG in the tongue and trachea of Swiss mice exposed to narghile smoke.Journal of applied oral science : revista FOB · 2026Article
- Current and Emerging Protein Biomarkers for the Diagnosis and Prognosis of Head and Neck Cancer.Genes · 2025Review
- The impact of histology and molecular biology in refining the prognostic value of surgical margins in head and neck oncology - A narrative review.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025Article
- Oral squamous cell carcinomas: state of the field and emerging directions.International journal of oral science · 2023Review
- Impact of preanalytical freezing delay time on the stability of metabolites in oral squamous cell carcinoma tissue samples.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- Occurrence of quadruple squamous cell carcinoma following allogeneic hematopoietic stem cell transplantation for leukemia: A case report.Oncology letters · 2021Article
- Molecular margins in head and neck cancer: Current techniques and future directions.Oral oncology · 2020Review
- Molecular biology of oral cavity squamous cell carcinoma.Oral oncology · 2020Article
- Margin Analysis in Head and Neck Cancer: State of the Art and Future Directions.Annals of surgical oncology · 2019Review
- Amino acids signatures of distance-related surgical margins of oral squamous cell carcinoma.EBioMedicine · 2019Article
- Expression of p53 at invasive front of oral squamous cell carcinoma and negative histopathological surgical margins to establish correlation at 3-year survival.Journal of oral and maxillofacial pathology : JOMFPArticle
- Angiotensin-converting Enzyme 2 Expression in Oral Squamous Cell Carcinoma: Correlation with p53 and Vascular Endothelial Growth Factor Using Reverse Transcriptase Polymerase Chain Reaction - An Evaluative Study.Annals of maxillofacial surgeryArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis was a retrospective analysis of the impact of the expression of p53 in the dys-plastic surgical margins of early oral squamous cell carcinoma (OSCC) (pT1-2, N0). PATIENTS AND
methodsSeventy-two patients with early oral squamous cell carcinoma (OSCC) were recruited. Margin characteristics were abstracted from the pathology report. Expression of p53 in dysplastic surgical margins was examined with the immunohistochemical method and was correlated with clinicopathological parameters and clinical outcomes.
resultsPatients with moderate/severe dysplasia had poor local relapse-free survival (RFS) compared to those with mild dysplasia. Thirty-two (44.4%) had at least one p53-positive margin, and there was a significant association between the expression of p53 and tumor recurrence (
conclusionOur results validated that p53 expression was an independent risk factor for early OSCC with dysplastic surgical margins. Additional therapy and close follow-up are needed for these patients.
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