ReviewJournal of pain research2019
Could epigenetics help explain racial disparities in chronic pain?
Review in Journal of pain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06418295 (Cytokine Alterations Associated With Persistent Post-surgical Pain and Their Regulation Through Epigenetic Changes - A Pilot Study), which is not on this map. Cited by 52 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cytokine Alterations Associated With Persistent Post-surgical Pain and Their Regulation Through Epigenetic Changes - A Pilot Study
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Epigenetic Factors Related to Low Back Pain: A Systematic Review of the Current Literature.International journal of molecular sciences · 2023Pooled it
- The Potential Contribution of Chronic Pain and Common Chronic Pain Conditions to Subsequent Cognitive Decline, New Onset Cognitive Impairment, and Incident Dementia: A Systematic Review and Conceptual Model for Future Research.Journal of Alzheimer's disease : JAD · 2020Pooled it
- Racial Disparities in Pain Among Women with Fibromyalgia: Secondary Data Analysis of Severity, Interference with Function, and Response to Guided Imagery.Journal of integrative and complementary medicine · 2023Trial
- Pain, symptom distress, and pain barriers by age among patients with cancer receiving hospice care: Comparison of baseline data.Journal of geriatric oncology · 2021Trial
- Cumulative Stress Burden and Association With DNA Methylation in Ethiopian American Immigrants: Protocol for a Community-Engaged, Biopsychosocial Study.JMIR research protocols · 2026Article
- Differential Association of Inflammation With Pain and Physical Function in Knee Osteoarthritis by Race Focusing on Non-Hispanic Whites and Asian Americans: Pilot Study in Florida.Asian/Pacific Island nursing journal · 2026Article
- Epigenomics in Understanding Racial Disparities of Alzheimer's Disease and Related Dementias.International journal of molecular sciences · 2026Review
- Racial disparities in ankylosing spondylitis risk following tonsillectomy: a large-scale retrospective analysis.Frontiers in immunology · 2026Article
- Social Determinants of Health Among Individuals Receiving Opioids for Pain Management.The Clinical journal of pain · 2025Article
- Neonatal pain experience and pain sensitivity trajectories in preterm infants: A longitudinal study of flexion withdrawal reflex thresholds over the first two years of age.The journal of pain · 2025Article
- Sociodemographically differential patterns of chronic pain progression revealed by analyzing the all of us research program data.PLOS digital health · 2025Article
- Unspoken Consequences of Structural Racism in the USA: Diabetes and COVID-19.Journal of racial and ethnic health disparities · 2024Review
- Social Determinants and Consequences of Pain: Toward Multilevel, Intersectional, and Life Course Perspectives.The journal of pain · 2024Review
- A Multigenerational Model of Environmental Risk for Black, Indigenous, and People of Color (BIPOC) Children and Families.Environmental health perspectives · 2024Article
- N4-acetylcytidine acetylation of neurexin 2 in the spinal dorsal horn regulates hypersensitivity in a rat model of cancer-induced bone pain.Molecular therapy. Nucleic acids · 2024Article
- The Long Shadow of Early Poverty: Poverty at Birth, Epigenetic Changes at Age 15, And Youth Outcomes at Age 22.Current research in public health · 2024Article
- The use of race terms in epigenetics research: considerations moving forward.Frontiers in genetics · 2024Article
- The incidence, characteristics, impact and risk factors of post-COVID chronic pain in Thailand: A single-center cross-sectional study.PloS one · 2024Article
- Attending to Marginalization in The Chronic Pain Literature: A Scoping Review.Canadian journal of pain = Revue canadienne de la douleur · 2024Article
- From stepping stones to scaling mountains: overcoming racialized disparities in pain management.Pain management · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
African Americans disproportionately suffer more severe and debilitating morbidity from chronic pain than do non-Hispanic Whites. These differences may arise from differential exposure to psychosocial and environmental factors such as adverse childhood experiences, racial discrimination, low socioeconomic status, and depression, all of which have been associated with chronic stress and chronic pain. Race, as a social construct, makes it such that African Americans are more likely to experience different early life conditions, which may induce epigenetic changes that sustain racial differences in chronic pain. Epigenetics is one mechanism by which environmental factors such as childhood stress, racial discrimination, economic hardship, and depression can affect gene expression without altering the underlying genetic sequence. This article provides a narrative review of the literature on epigenetics as a mechanism by which differential environmental exposure could explain racial differences in chronic pain. Most studies of epigenetic changes in chronic pain examine DNA methylation. DNA methylation is altered in the glucocorticoid (stress response) receptor gene,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.