ReviewInternational journal of general medicine2019
Effects of blood flow restriction exercise on hemostasis: a systematic review of randomized and non-randomized trials.
Review in International journal of general medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 10 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Upper extremity pain after stroke: a systematic review and meta-analysis on primary prevention.European journal of physical and rehabilitation medicine · 2025Pooled it
- Impact of team-based primary care on health care utilization among patients with mental and substance use disorders: a systematic review of English-language articles.Family practice · 2025Pooled it
- Blood flow restriction combined with resistance training on muscle strength and thickness improvement in young adults: a systematic review, meta-analysis, and meta-regression.Frontiers in physiology · 2024Pooled it
- The diagnostic value of physical examination tests in adhesive capsulitis: a systematic review.European journal of physical and rehabilitation medicine · 2023Pooled it
- Effect of mobile application types on stroke rehabilitation: a systematic review.Journal of neuroengineering and rehabilitation · 2023Pooled it
- Systematic review and rationale of using psychedelics in the treatment of cannabis use disorder.Frontiers in psychiatry · 2023Pooled it
- Effects of Low-Load Blood Flow Restriction Training on Hemodynamic Responses and Vascular Function in Older Adults: A Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Effect of Blood Flow Restriction on Functional, Physiological and Structural Variables of Muscle in Patients with Chronic Pathologies: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Clinical outcome measures and scoring systems used in prospective studies of port wine stains: A systematic review.PloS one · 2020Pooled it
- A Meta-analysis on Interventional Metrics of Transjugular Intrahepatic Portosystemic Shunt Placement With Cone-beam Computed Tomography Guidance and Fluoroscopy Guidance.In vivo (Athens, Greece)Pooled it
- Rehabilitation efficacy of Low-Load blood flow restriction training for lateral patellar compression syndrome.Journal of orthopaedic surgery and research · 2026Trial
- Comparison of Quadriceps and Hamstring Muscle Strength after Exercises with and without Blood Flow Restriction following Anterior Cruciate Ligament Surgery: A Randomized Controlled Trial.Journal of rehabilitation medicine · 2022Trial
- Blood Flow Restriction Training in Hemodialysis Patients: Clinical Benefits, Challenges, and Future Perspectives.Hemodialysis international. International Symposium on Home Hemodialysis · 2026Review
- Cross-Platform Transcriptomic Analysis of 40 Human and Rodent Skeletal Muscle Exerkines.Muscles (Basel, Switzerland) · 2026Review
- Examining the impact of blood flow restriction on cardiac rehabilitation outcomes.World journal of cardiology · 2025Review
- The effect of preoperative interventions on postoperative outcomes following elective hand surgery: A systematic review.Hand therapy · 2025Review
- The effects of blood flow restriction combined with endurance training on athletes' aerobic capacity, lower limb muscle strength, anaerobic power and sports performance: a meta-analysis.BMC sports science, medicine & rehabilitation · 2025Article
- Blood Flow Restriction Use by U.S. Physical Therapists: A Survey on Settings, Equipment, and Adverse Effects.International journal of exercise science · 2025Article
- Serum tissue plasminogen activator after cycling with blood flow restriction.Vascular biology (Bristol, England) · 2025Article
- Concerns about the application of resistance exercise with blood-flow restriction and thrombosis risk in hemodialysis patients.Journal of sport and health science · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBlood flow restriction (BFR) exercise has shown to induce a positive influence on bone metabolism and attenuate muscle strength loss and atrophy in subjects suffering from musculoskeletal weakness. Despite the known benefits of BFR exercise, it remains unclear whether or not the pressurization of blood vessels damages the endothelial cells or increases risk for formation of thrombi. Thus, the effects of BFR exercise on coagulation, fibrinolysis, or hemostasis, remains speculative.
objectiveThe aim of the present study was to perform a systematic review of the short and long- term effects of BFR exercise on blood hemostasis in healthy individuals and patients with known disease (ie, hypertension, diabetes, obesity, and ischemic heart disease). DATA SOURCES: A systematic review of English and non-English articles was conducted across PubMed, Science Direct, and Google Scholar databases, including reference lists of relevant papers. Study quality assessment was evaluated using the modified version of Downs and Black checklist. Search results were limited to exercise training studies investigating the effects of BFR exercise on blood hemostasis in healthy individuals and patients with disease. Level of evidence was determined according to the criteria described by Oxford Center for Evidence-Based Medicine. STUDY SELECTION: Only randomized controlled trials (RCTs) and non-randomized controlled trials (NRCTs) that examined the effects of exercise with BFR exercise vs exercises without BFR on blood hemostasis in healthy individuals and patients were included. DATA EXTRACTION: Nine studies were eligible (RCT =4; NRCT =5).
resultsThe average score on the Downs and Black checklist was 11.22. All studies were classified as having poor methodological quality wherein the level of evidence provided in all reviewed studies was level IIb only (ie, poor quality RCTs).
conclusionConsidering the limitations in the available evidence, firm recommendations cannot be provided.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.