ArticleInfection and drug resistance2019
Treatment of late bacterial infections resulting from soft-tissue filler injections.
Article in Infection and drug resistance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Late Subcutaneous Infection Caused by Serratia marcescens Following Hyaluronic Acid Injection: A Case Report and Systemic Review.Journal of cosmetic dermatology · 2025Pooled it
- Impact of SARS-CoV-2 Vaccination or Infection on the Safety and Efficacy of Aesthetic Injections: A Systematic Review.Aesthetic plastic surgery · 2024Pooled it
- Late inflammatory reactions in patients with soft tissue fillers after SARS-CoV-2 infection and vaccination: A systematic review of the literature.Journal of cosmetic dermatology · 2022Pooled it
- The Aetiopathogenesis of Late Inflammatory Reactions (LIRs) After Soft Tissue Filler Use: A Systematic Review of the Literature.Aesthetic plastic surgery · 2021Pooled it
- Comparison of the effects of submucosal hyaluronidase and dexamethasone on postoperative edema, pain, trismus, and infection following impacted third molar surgery.BMC oral health · 2024Trial
- Labial Angioedema and Bacterial and Viral Infection Following Hyaluronic Acid Injection.Cureus · 2026Article
- Late-Onset Reactions after Hyaluronic Acid Dermal Fillers: A Consensus Recommendation on Etiology, Prevention and Management.Dermatology and therapy · 2024Review
- A Rare Infection Post Hyaluronic Acid Injection in the Trochanter: Case Report and Literature Review.Aesthetic surgery journal. Open forum · 2024Article
- Oral Methotrexate Treatment of Delayed-Onset Inflammatory Reactions to Dermal Fillers.Aesthetic surgery journal. Open forum · 2024Article
- Efficacy and complications of hyaluronic acid and polylactic acid for penile augmentation: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2023Review
- Hyaluronic acid fillers may be longer-lasting than previously described: A case report of delayed filler-associated facial cellulitis.JPRAS open · 2022Article
- Complications of Nonpermanent Facial Fillers: A Systematic Review.Plastic and reconstructive surgery. Global open · 2021Article
- Article
- Infected Facial Tissue Fillers Caused by Dental Infection.Case reports in dentistry · 2021Article
- Catastrophic complications from filler injection on external genitalia.Archives of plastic surgery · 2021Article
- The impact of lifestyle upon the probability of late bacterial infection after soft-tissue filler augmentation.Infection and drug resistance · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLate bacterial infections (LBIs) after esthetic facial augmentation using hyaluronic acid (HA) fillers are relatively rare yet severe complications that are difficult to treat. No adequate treatment standards have hitherto been formulated. We have bridged this gap by formulating a treatment scheme based on the principles of treating foreign-body implantation-related infections and treating bacterial growth in the form of biofilm. The objective of this study was to evaluate the efficacy of a comprehensive scheme for treating LBI complications after facial augmentation using cross-linked HA fillers.
methodsA total of 22 patients with LBI symptoms at a site of cross-linked HA injection underwent treatment and observation. The comprehensive treatment scheme formulated by Marusza and Netsvyetayeva (M&N scheme) comprised draining the lesion, dissolution of cross-linked HA with hyaluronidase, broad-spectrum antibiotic combination therapy, and use of probiotics. While 17 patients underwent the M&N scheme, the remaining five were treated with other schemes. Statistical analysis of the data was performed using Mann-Whitney
resultsAll 17 patients who underwent the M&N scheme experienced resolution of symptoms, with no recurrence of infection at the HA-injection sites.
conclusionTo treat LBI at a site of cross-linked HA administration, the principles applicable to infections resulting from implantation of a foreign body must be followed. The treatment period should be sufficiently long for complete resolution of symptoms. The efficacy of treatment is considered proven if 2 months have elapsed without recurrence since the symptoms resolved. The M&N scheme is recommended for use as the first therapeutic option for treating LBI related to soft-tissue fillers.
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