Evidence map›Paper›PMID 30863111›Full record

ArticleOncoTargets and therapy2019

Impact of liver kinase B1 on p53 and survivin and its correlation with prognosis in gastric cancer.

Weiwei Li, Shunxiang Luo, Guowei Ma, Lin Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in OncoTargets and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Weiwei LiDepartment of Oncology, The First People's Hospital of Tianmen City, Hubei, China.
Shunxiang LuoDepartment of Oncology, The First People's Hospital of Tianmen City, Hubei, China.
Guowei MaDepartment of Gastrointestinal Surgery, The First People's Hospital of Tianmen City, Hubei, China.
Lin WangDepartment of Pathology, The First People's Hospital of Tianmen City, Hubei, China, linwang0110@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiver kinase B1 (LKB1) is a newly discovered tumor suppressor gene that plays a role in apoptosis induction. However, the precise impact of LKB1 expression on gastric cancer (GC) progression and its correlation with survivin and p53 in GC have not yet been elucidated. PURPOSE: The aim of this study was to explore the significance of LKB1 expression and its correlation with p53 and survivin in GC. PATIENTS AND

methodsIn this study, LKB1 expression was detected in GC and adjacent paracancerous tissues from 150 patients through immunohistochemical (IHC) staining. The relationship between LKB1 expression and clinical pathological factors in GC was analyzed, alongside its correlation with p53 and survivin expression.

resultsLKB1 expression was reduced in GC tissues compared with adjacent paracancerous tissues (

conclusionOur study suggests that LKB1 expression is reduced in GC, negatively correlated with p53 and survivin expression, and plays an important role in predicting invasion and metastasis of GC.

Indexed as

gastric cancerliver kinase B1p53prognosissurvivin

Identifiers

PMID30863111
PMCPMC6390856

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.