Evidence map›Paper›PMID 30863066›Full record

ReviewInternational journal of nanomedicine2019

Slp-coated liposomes for drug delivery and biomedical applications: potential and challenges.

Gan Luo, Qingliang Yang, Bingpeng Yao, Yangfan Tian, Ruixia Hou, Anna Shao, Mengting Li, Zilin Feng, Wenxi Wang

Abstract readReview
In one paragraph

Review in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Nanobodies: a new potential for prostate cancer treatment.Journal of cancer research and clinical oncology · 2023
    Review
  6. Review
  7. Article
  8. Review
  9. ThePNAS nexus · 2022
    Article
  10. Article
  11. Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gan LuoDepartment of Pharmaceutics, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China, yjw@zjut.edu.cn.
Qingliang YangDepartment of Pharmaceutics, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China, yjw@zjut.edu.cn.
Bingpeng YaoDepartment of Pharmaceutics, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China, yjw@zjut.edu.cn.
Yangfan TianDepartment of Pediatric Surgery, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Ruixia HouDepartment of Pharmaceutics, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China, yjw@zjut.edu.cn.
Anna ShaoDepartment of Pharmaceutics, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China, yjw@zjut.edu.cn.
Mengting LiDepartment of Pharmaceutics, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China, yjw@zjut.edu.cn.
Zilin FengDepartment of Pharmaceutics, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China, yjw@zjut.edu.cn.
Wenxi WangDepartment of Pharmaceutics, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China, yjw@zjut.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Slp forms a crystalline array of proteins on the outermost envelope of bacteria and archaea with a molecular weight of 40-200 kDa. Slp can self-assemble on the surface of liposomes in a proper environment via electrostatic interactions, which could be employed to functionalize liposomes by forming Slp-coated liposomes for various applications. Among the molecular characteristics, the stability, adhesion, and immobilization of biomacromolecules are regarded as the most meaningful. Compared to plain liposomes, Slp-coated liposomes show excellent physicochemical and biological stabilities. Recently, Slp-coated liposomes were shown to specifically adhere to the gastrointestinal tract, which was attributed to the "ligand-receptor interaction" effect. Furthermore, Slp as a "bridge" can immobilize functional biomacromol-ecules on the surface of liposomes via protein fusion technology or intermolecular forces, endowing liposomes with beneficial functions. In view of these favorable features, Slp-coated liposomes are highly likely to be an ideal platform for drug delivery and biomedical uses. This review aims to provide a general framework for the structure and characteristics of Slp and the interactions between Slp and liposomes, to highlight the unique properties and drug delivery as well as the biomedical applications of the Slp-coated liposomes, and to discuss the ongoing challenges and perspectives.

Indexed as

Drug Delivery SystemsBiomedical TechnologyLiposomesMembrane GlycoproteinsStatic ElectricityLiposomesMembrane GlycoproteinsS-layer proteinsbiomedical applicationsdrug deliveryinteractionsliposomesself-assemblyS-layer protein

Identifiers

PMID30863066
PMCPMC6388732

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.