Evidence map›Paper›PMID 30863051›Full record

ArticleInternational journal of nanomedicine2019

A chemoenzymatically synthesized cholesterol-g-poly(amine-co-ester)-mediated

Mengmeng Dong, Jiawen Chen, Jiayuan Zhang, Xiao Liang, Jiebing Yang, Dan Li, Quanshun Li

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Baicalin-modified polyethylenimine for miR-34a efficient and safe delivery.Frontiers in bioengineering and biotechnology · 2023
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Mengmeng DongDepartment of Cancer Center, The First Hospital of Jilin University, Changchun 130021, People's Republic of China, lidan2009@jlu.edu.cn.
Jiawen ChenKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, People's Republic of China, quanshun@jlu.edu.cn.
Jiayuan ZhangKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, People's Republic of China, quanshun@jlu.edu.cn.
Xiao LiangKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, People's Republic of China, quanshun@jlu.edu.cn.
Jiebing YangKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, People's Republic of China, quanshun@jlu.edu.cn.
Dan LiDepartment of Cancer Center, The First Hospital of Jilin University, Changchun 130021, People's Republic of China, lidan2009@jlu.edu.cn.
Quanshun LiKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, People's Republic of China, quanshun@jlu.edu.cn.
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn amphiphilic cationic copolymer cholesterol-g-poly(amine-co-ester), namely Chol-g-PMSC-PPDL synthesized in a chemoenzymatic route has been utilized as a carrier for MATERIALS AND

methodsThe transfection efficiency was measured by quantitative PCR and Western blotting assay. The anti-proliferative effect was detected using MTT method, colony formation assay and Live/Dead staining. The anti-migration effect was evaluated through wound healing and Transwell migration assays.

resultsThe transfection efficiency assay indicated that the carrier-mediated

conclusionChol-

Indexed as

Gene Transfer TechniquesApoptosisCell Line, TumorCell ProliferationCell SurvivalCholesterol EstersHumansMaleNanoparticlesProstatic NeoplasmsRNA, MessengerTumor Suppressor Protein p53Wound HealingCholesterol EstersRNA, MessengerTumor Suppressor Protein p53anti-migration effectanti-proliferation effectcholesterol-g-poly(amine-co-ester)gene therapyp53 gene delivery

Identifiers

PMID30863051
PMCPMC6391147
OpenAlexW2914229506

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.