ArticleScientific reports2019
Deep structural brain lesions associated with consciousness impairment early after hemorrhagic stroke.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05479032 (Amantadine for Neuroenhancement in Acute Patients Study - A Prospective Pilot Proof of Concept Phase IIb Study in Intensive and Intermediate Care Unit Patients), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Amantadine for Neuroenhancement in Acute Patients Study - A Prospective Pilot Proof of Concept Phase IIb Study in Intensive and Intermediate Care Unit Patients
Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- The neural basis of explicit and implicit emotion regulation: a coordinate-based meta-analysis.Oxford open neuroscience · 2026Review
- Integrating qualitative and quantitative MRI analysis for optimizing DBS candidate selection in patients with disorders of consciousness.Frontiers in neurology · 2025Article
- Explaining recovery from coma with multimodal neuroimaging.Journal of neurology · 2024Observational
- Neuroimaging in Disorders of Consciousness and Recovery.Physical medicine and rehabilitation clinics of North America · 2024Review
- Neuro-imaging in intracerebral hemorrhage: updates and knowledge gaps.Frontiers in neuroscience · 2024Review
- Injury patterns associated with cognitive motor dissociation.Brain : a journal of neurology · 2023Article
- Brain Circuitry of Consciousness: A Review of Current Models and a Novel Synergistic Model With Clinical Application.Neurosurgery practice · 2023Article
- Applications of Advanced MRI to Disorders of Consciousness.Seminars in neurology · 2022Review
- Thalamo-Prefrontal Connectivity Correlates With Early Command-Following After Severe Traumatic Brain Injury.Frontiers in neurology · 2022Article
- Electrocorticography reveals thalamic control of cortical dynamics following traumatic brain injury.Communications biology · 2021Article
- Intracerebral Hemorrhage with Intraventricular Extension Associated with Loss of Consciousness at Symptom Onset.Neurocritical care · 2021Article
- Discriminating cognitive motor dissociation from disorders of consciousness using structural MRI.NeuroImage. Clinical · 2021Article
- Coma science: intensive care as the new frontier.Intensive care medicine · 2020Article
- Lagged Correlations among Physiological Variables as Indicators of Consciousness in Stroke Patients.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2019Article
Corrections and comments
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Authors and funding
19 authors at 4 institutions in 4 countries.
Funding
Abstract
The purpose of this study was to determine the significance of deep structural lesions for impairment of consciousness following hemorrhagic stroke and recovery at ICU discharge. Our study focused on deep lesions that previously were implicated in studies of disorders of consciousness. We analyzed MRI measures obtained within the first week of the bleed and command following throughout the ICU stay. A machine learning approach was applied to identify MRI findings that best predicted the level consciousness. From 158 intracerebral hemorrhage patients that underwent MRI, one third was unconscious at the time of MRI and half of these patients recovered consciousness by ICU discharge. Deep structural lesions predicted both, impairment and recovery of consciousness, together with established measures of mass effect. Lesions in the midbrain peduncle and pontine tegmentum alongside the caudate nucleus were implicated as critical structures. Unconscious patients predicted to recover consciousness by ICU discharge had better long-term functional outcomes than those predicted to remain unconscious.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.