Evidence map›Paper›PMID 30862859›Full record

ArticleScientific reports2019

Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the A

Jing Yong, Jide Tian, Hoa Dang, Ting-Ting Wu, Mark A Atkinson, Ren Sun, Daniel L Kaufman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jing YongDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90095-1735, United States.
Jide TianDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90095-1735, United States.
Hoa DangDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90095-1735, United States.
Ting-Ting WuDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90095-1735, United States.
Mark A AtkinsonDepartments of Pathology and Paediatrics, University of Florida Diabetes Institute, Gainesville, FL, 32610, United States.
Ren SunDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90095-1735, United States.
Daniel L KaufmanDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90095-1735, United States. dkaufman@mednet.ucla.edu.
University of California, Los Angeles · USUniversity of Florida · US

Funding

Virology CoreP01CA177322 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUN, REN · 2014 to 2018
$8.7M
Develop a therapeutic vaccine approach by removing viral immune evasionR01DE023591 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUN, REN · 2013 to 2017
$1.9M
Reversal of T1D in NOD mice using a safe combination therapyR01DK092480 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KAUFMAN, DANIEL · 2012 to 2015
$1.3M
NCI NIH HHS P01 CA177322NIDCR NIH HHS R01 DE023591NIDDK NIH HHS R01 DK092480
6 · The paper itself

Abstract

There has been considerable debate as to whether obesity can act as an accelerator of type 1 diabetes (T1D). We assessed this possibility using transgenic mice (MIP-TF mice) whose ß-cells express enhanced green fluorescent protein (EGFP). Infecting these mice with EGFP-expressing murine herpes virus-68 (MHV68-EGFP) caused occasional transient elevation in their blood glucose, peri-insulitis, and Th1 responses to EGFP which did not spread to other ß-cell antigens. We hypothesized that obesity-related systemic inflammation and ß-cell stress could exacerbate the MHV68-EGFP-induced ß-cell autoreactivity. We crossed MIP-TF mice with A

Indexed as

Agouti Signaling ProteinAnimalsAutoantigensAutoimmunityBlood GlucoseDiabetes Mellitus, Type 1Diet, High-FatDisease Models, AnimalHumansInsulin-Secreting CellsMiceMice, TransgenicMutationObesityT-LymphocytesAgouti Signaling Proteina protein, mouseAutoantigensBlood Glucose

Identifiers

PMID30862859
PMCPMC6414670
OpenAlexW2921472396

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.