ArticleScientific reports2019
Frequency-specific activation of the peripheral auditory system using optoacoustic laser stimulation.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Optical induction of auditory perception via cochlear stimulation in Mongolian gerbils without genetic modification.iScience · 2026Article
- Intensity modulation of frequency-specific optoacoustic stimulation at the peripheral hearing level.Zeitschrift fur medizinische Physik · 2026Article
- Acoustic stimulation of the human round window by laser-induced nonlinear optoacoustics.Scientific reports · 2024Article
- Optoacoustically induced auditory brainstem responses in the mouse model enhanced through an absorbing film.Journal of biomedical optics · 2021Article
- Wavelength-specific optoacoustic-induced vibrations of the guinea pig tympanic membrane.Journal of biomedical optics · 2021Article
- Cytotoxicity studies of an optoacoustic stimulation strategy for the development of laser-based hearing aids.Journal of biomedical optics · 2020Article
- First biocompatibility margins for optical stimulation at the eardrum via 532-nm laser pulses in a mouse model.Journal of biomedical optics · 2019Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Hearing impairment is one of the most common sensory deficits in humans. Hearing aids are helpful to patients but can have poor sound quality or transmission due to insufficient output or acoustic feedback, such as for high frequencies. Implantable devices partially overcome these issues but require surgery with limited locations for device attachment. Here, we investigate a new optoacoustic approach to vibrate the hearing organ with laser stimulation to improve frequency bandwidth, not requiring attachment to specific vibratory structures, and potentially reduce acoustic feedback. We developed a laser pulse modulation strategy and simulated its response at the umbo (1-10 kHz) based on a convolution-based model. We achieved frequency-specific activation in which non-contact laser stimulation of the umbo, as well as within the middle ear at the round window and otic capsule, induced precise shifts in the maximal vibratory response of the umbo and neural activation within the inferior colliculus of guinea pigs, corresponding to the targeted, modelled and then stimulated frequency. There was also no acoustic feedback detected from laser stimulation with our experimental setup. These findings open up the potential for using a convolution-based optoacoustic approach as a new type of laser hearing aid or middle ear implant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.