Evidence map›Paper›PMID 30862784›Full record

ArticleNature communications2019

Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels.

Martin Vaeth, Yin-Hu Wang, Miriam Eckstein, Jun Yang, Gregg J Silverman, Rodrigo S Lacruz, Kasthuri Kannan, Stefan Feske

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
5.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Analysis of Store-Operated CaMethods in molecular biology (Clifton, N.J.) · 2025
    Article
  11. Article
  12. Review
  13. IFN-γ-producing TScience translational medicine · 2024
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Martin VaethDepartment of Pathology, New York University School of Medicine, New York, NY, 10016, USA.ORCID http://orcid.org/0000-0001-8974-7052
Yin-Hu WangDepartment of Pathology, New York University School of Medicine, New York, NY, 10016, USA.
Miriam EcksteinDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY, 10010, USA.
Jun YangDepartment of Pathology, New York University School of Medicine, New York, NY, 10016, USA.
Gregg J SilvermanDepartment of Medicine, New York University School of Medicine, New York, NY, 10016, USA.ORCID http://orcid.org/0000-0001-9480-9457
Rodrigo S LacruzDepartment of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY, 10010, USA.
Kasthuri KannanDepartment of Pathology, New York University School of Medicine, New York, NY, 10016, USA.
Stefan FeskeDepartment of Pathology, New York University School of Medicine, New York, NY, 10016, USA. feskes01@nyumc.org.
New York University · USUniversity of Würzburg · DENew York Genome Center · US

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
Translational Center of Molecular Profiling in Preclinical and Established Lupus (COMPEL)P50AR070591 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI IZMIRLY, PETER · 2017 to 2021
$6.7M
CRAC Channel Deficiency in Immunity to InfectionR01AI097302 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2012 to 2022
$5.6M
Redox and Ca2+ signaling regulation of enamel mineralizationR01DE027679 · NIDCR · NEW YORK UNIVERSITY · PI Rodrigo S. Lacruz · 2018 to 2026
$3.3M
Ca2+ signaling via SOCE in the pathogenesis of Sjögren’s syndromeR01DE027981 · NIDCR · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN, LACRUZ, RODRIGO S. · 2019 to 2023
$2.7M
Regulation of Follicular T cell Responses in the Lung by Ion ChannelsR01AI130143 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2017 to 2021
$2.4M
Regulation of encephalitogenic T cells by CRAC channelsR01AI137004 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2018 to 2022
$2.4M
Calcium Control of Enamel DevelopmentR01DE025639 · NIDCR · NEW YORK UNIVERSITY · PI LACRUZ, RODRIGO S. · 2016 to 2020
$2.0M
NCI NIH HHS P30 CA016087NIAID NIH HHS HHSN272201400019CNIAID NIH HHS R01 AI097302NIAID NIH HHS R01 AI130143NIAID NIH HHS R01 AI137004NIAMS NIH HHS P50 AR070591NIDCR NIH HHS R01 DE025639NIDCR NIH HHS R01 DE027679NIH HHS AI097302NIH HHS AI130143NIH HHS AI137004NIH HHS DE025639NIH HHS P30CA016087NIH HHS P50 AR070591-01A
6 · The paper itself

Abstract

T regulatory (Treg) cells maintain immunological tolerance and organ homeostasis. Activated Treg cells differentiate into effector Treg subsets that acquire tissue-specific functions. Ca

Indexed as

AnimalsAutoantibodiesAutoimmune DiseasesBone Marrow TransplantationCalciumCalcium Release Activated Calcium ChannelsCations, DivalentCell DifferentiationDisease Models, AnimalFemaleForkhead Transcription FactorsHumansMaleMiceMice, Inbred C57BLMice, KnockoutAutoantibodiesCalciumCalcium Release Activated Calcium ChannelsCations, DivalentForkhead Transcription FactorsFoxp3 protein, mouseStim1 protein, mouseStim2 protein, mouseStromal Interaction Molecule 1Stromal Interaction Molecule 2

Identifiers

PMID30862784
PMCPMC6414608
OpenAlexW2921789782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.