ArticleNature communications2019
Dynamic molecular changes during the first week of human life follow a robust developmental trajectory.
3 registry-linked trialsAbstract readValidation Study
In one paragraph
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 136 papers.
0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Systems Biology to Identify Biomarkers of Neonatal Vaccine Immunogenicity
Yellow Fever Vaccine Booster Trial in Children- a Phase 3 Clinical Trial to Establish Safety and Immunogenicity of Repeated YF Vaccination in Healthy Gambian Children of Different Ages
Description and Comparison of Biological Vulnerability in Small Vulnerable Newborns Versus Healthy Community Controls in Urban Burkina Faso (DenBalo): Gut Microbiota, Immune System, and Breastmilk Assembly and Development in the First Days and Weeks of Life
Who cites it
136 citing papers in PubMed.
- Calorie-restricted oat diet is associated with zonulin and short-chain fatty acid response in metabolic syndrome: a randomized controlled trial.Gut microbes · 2026Trial
- Cholesterol-lowering effects of oats induced by microbially produced phenolic metabolites in metabolic syndrome: a randomized controlled trial.Nature communications · 2026Trial
- Preventing Sepsis in Preterm Infants with Bovine Lactoferrin: A Randomized Trial Exploring Immune and Antioxidant Effects.Nutrients · 2025Trial
- Safety and implementation of phase I randomized GLA-SE-adjuvanted CH505TF gp120 HIV vaccine trial in newborns.The Journal of clinical investigation · 2025Trial
- The influence of neonatal BCG vaccination on in vitro cytokine responses to Plasmodium falciparum.BMC immunology · 2024Trial
- Breastfeeding and Neonatal Age Influence Neutrophil-Driven Ontogeny of Blood Cell Populations in the First Week of Human Life.Journal of immunology research · 2024Trial
- Plasticity of the infant immune system during the perinatal period.Nature reviews. Immunology · 2026Review
- Population-specific heterogeneity in ontogeny of the broadly-conserved blood transcriptional program during the first week of life.Nature communications · 2026Article
- Immune development in early life.Nature immunology · 2026Review
- Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD.Annals of clinical and translational neurology · 2026Article
- A randomized prospective study of neonatal hepatitis B vaccine immunogenicity in The Gambia and Papua New Guinea.The journal of allergy and clinical immunology. Global · 2026Article
- Mapping Infant Immunity with Minimal Input: Integrative Single-cell and Multiomic Profiling.Journal of visualized experiments : JoVE · 2026Article
- First-year dynamics of the plasma virome and cytokine profile in infants born to mothers with syphilis.Journal of translational medicine · 2026Article
- Systems biology approaches to unravelling neonatal sepsis and potential for precision diagnostics and therapeutics.Frontiers in pharmacology · 2026Review
- Integration of Preclinical and Clinical Vaccine Safety and Immunogenicity Testing for Development of a Pediatric HIV Vaccine to Achieve Protective HIV Immunity Prior to Adolescence.Current HIV research · 2026Review
- Reduced NLRP3, AIM2 and NLRC4 inflammasome activity in cord blood of extremely preterm infants.Frontiers in pediatrics · 2026Article
- The BCGMethodsX · 2025Article
- Gut Microbial Genetic Variation Prolongs Host Healthy Longevity and Remodels Metabolome and Proteome in Drosophila Melanogaster.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Protein-level batch-effect correction enhances robustness in MS-based proteomics.Nature communications · 2025Article
- Immune Development in Early Life (IDEaL) longitudinal cohort study protocol: Identifying biomarkers of vaccine responsiveness, respiratory infection, and asthma.The journal of allergy and clinical immunology. Global · 2025Article
76 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
44 authors.
Amy H LeeDepartment of Microbiology & Immunology, University of British Columbia, 1365-2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada.ORCID http://orcid.org/0000-0003-3250-3246
Casey P ShannonPROOF Centre of Excellence, 10th Floor, 1190 Hornby Street, Vancouver, BC, V6Z 2K5, Canada.ORCID http://orcid.org/0000-0002-5687-3156
Nelly AmenyogbeDepartment of Experimental Medicine, University of British Columbia, 2775 Laurel Street, 10th Floor, Room 10117, Vancouver, BC, V5Z 1M9, Canada.
Tue B BennikeDepartment of Pathology, Boston Children's Hospital, BCH 3108, 300 Longwood Ave, Boston, MA, 02115, USA.ORCID http://orcid.org/0000-0003-4354-1731
Joann Diray-ArcePrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, 300 Longwood Ave, BCH 3104, Boston, MA, 02115, USA.
Olubukola T IdokoVaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, P.O. Box 273, Banjul, Gambia.
Erin E GillDepartment of Microbiology & Immunology, University of British Columbia, 1365-2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada.
Rym Ben-OthmanDepartment of Pediatrics, BC Children's Hospital, University of British Columbia, Rm 2D19, 4480 Oak Street, Vancouver, BC, V6H 3V4, Canada.
William S PomatPapua New Guinea Institute of Medical Research, Homate Street, Goroka, Eastern Highlands Province, Papua New Guinea.
Simon D van HarenPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, 300 Longwood Ave, BCH 3104, Boston, MA, 02115, USA.
Kim-Anh Lê CaoStatistical Genomics, School of Mathematics and Statistics, Melbourne Integrative Genomics, Centre for Systems Genomics, The University of Melbourne, Building 184 Ground Floor, Parkville, VIC, 3010, Australia.ORCID http://orcid.org/0000-0003-3923-1116
Momoudou CoxVaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, P.O. Box 273, Banjul, Gambia.
Alansana DarboeVaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, P.O. Box 273, Banjul, Gambia.ORCID http://orcid.org/0000-0002-1152-8156
Reza FalsafiDepartment of Microbiology & Immunology, University of British Columbia, 1365-2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada.
Davide FerrariStatistical Genomics, School of Mathematics and Statistics, Melbourne Integrative Genomics, Centre for Systems Genomics, The University of Melbourne, Building 184 Ground Floor, Parkville, VIC, 3010, Australia.
Daniel J HarbesonDepartment of Experimental Medicine, University of British Columbia, 2775 Laurel Street, 10th Floor, Room 10117, Vancouver, BC, V5Z 1M9, Canada.
Daniel HePROOF Centre of Excellence, 10th Floor, 1190 Hornby Street, Vancouver, BC, V6Z 2K5, Canada.ORCID http://orcid.org/0000-0002-9302-6036
Cai BingDepartment of Pediatrics, BC Children's Hospital, University of British Columbia, Rm 2D19, 4480 Oak Street, Vancouver, BC, V6H 3V4, Canada.
Samuel J HinshawDepartment of Microbiology & Immunology, University of British Columbia, 1365-2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada.
Jorjoh NdureVaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, P.O. Box 273, Banjul, Gambia.
Jainaba Njie-JobeVaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, P.O. Box 273, Banjul, Gambia.
Matthew A PettengillPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, 300 Longwood Ave, BCH 3104, Boston, MA, 02115, USA.
Peter C RichmondDivision of Paediatrics, School of Medicine, University of Western Australia, 35 Stirling Highway, Nedlands, WA, 6009, Australia.
Rebecca FordPapua New Guinea Institute of Medical Research, Homate Street, Goroka, Eastern Highlands Province, Papua New Guinea.
Gerard SaleuPapua New Guinea Institute of Medical Research, Homate Street, Goroka, Eastern Highlands Province, Papua New Guinea.
Geraldine MasiriaPapua New Guinea Institute of Medical Research, Homate Street, Goroka, Eastern Highlands Province, Papua New Guinea.
John Paul MatlamPapua New Guinea Institute of Medical Research, Homate Street, Goroka, Eastern Highlands Province, Papua New Guinea.
Wendy KirarockPapua New Guinea Institute of Medical Research, Homate Street, Goroka, Eastern Highlands Province, Papua New Guinea.
Elishia RobertsVaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, P.O. Box 273, Banjul, Gambia.
Mehrnoush MalekBC Cancer Agency, 686 West Broadway, Suite 500, Vancouver, BC, V5Z 1G1, Canada.
Guzmán Sanchez-SchmitzPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, 300 Longwood Ave, BCH 3104, Boston, MA, 02115, USA.
Amrit SinghPROOF Centre of Excellence, 10th Floor, 1190 Hornby Street, Vancouver, BC, V6Z 2K5, Canada.ORCID http://orcid.org/0000-0002-7475-1646
Asimenia AngelidouPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, 300 Longwood Ave, BCH 3104, Boston, MA, 02115, USA.
Kinga K SmolenPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, 300 Longwood Ave, BCH 3104, Boston, MA, 02115, USA.
EPIC Consortium
Ryan R BrinkmanBC Cancer Agency, 686 West Broadway, Suite 500, Vancouver, BC, V5Z 1G1, Canada.
Al OzonoffPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, 300 Longwood Ave, BCH 3104, Boston, MA, 02115, USA.
Robert E W HancockDepartment of Microbiology & Immunology, University of British Columbia, 1365-2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada.ORCID http://orcid.org/0000-0001-5465-3814
Anita H J van den BiggelaarWesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia Perth, 15 Hospital Avenue, Nedlands, WA, 6009, Australia.
Hanno SteenDepartment of Pathology, Boston Children's Hospital, BCH 3108, 300 Longwood Ave, Boston, MA, 02115, USA.ORCID http://orcid.org/0000-0003-0179-6648
Scott J TebbuttPROOF Centre of Excellence, 10th Floor, 1190 Hornby Street, Vancouver, BC, V6Z 2K5, Canada.ORCID http://orcid.org/0000-0002-7908-1581
Beate KampmannVaccines & Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, P.O. Box 273, Banjul, Gambia.
Ofer LevyPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, 300 Longwood Ave, BCH 3104, Boston, MA, 02115, USA. ofer.levy@childrens.harvard.edu.ORCID http://orcid.org/0000-0002-5859-1945
Tobias R KollmannDepartment of Experimental Medicine, University of British Columbia, 2775 Laurel Street, 10th Floor, Room 10117, Vancouver, BC, V5Z 1M9, Canada. tkollm@mac.com.ORCID http://orcid.org/0000-0003-2403-9762
Funding
Transcriptomics to define biomarkers of neonatal vaccine immunogenicityU19AI118608 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LEVY, OFER · 2017 to 2021
$24.7MDissecting the mechanism of age-specific adjuvant synergy in vitro and in vivoU01AI124284 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI LEVY, OFER · 2016 to 2020
$2.9MMedical Research Council MR/R005990/1NIAID NIH HHS HHSN272201400052CNIAID NIH HHS U01 AI124284NIAID NIH HHS U19 AI118608
Abstract
Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data from <1 ml of blood, a volume readily obtained from newborns. Indexing to baseline and applying innovative integrative computational methods reveals dramatic changes along a remarkably stable developmental trajectory over the first week of life. This is most evident in changes of interferon and complement pathways, as well as neutrophil-associated signaling. Validated across two independent cohorts of newborns from West Africa and Australasia, a robust and common trajectory emerges, suggesting a purposeful rather than random developmental path. Systems biology and innovative data integration can provide fresh insights into the molecular ontogeny of the first week of life, a dynamic developmental phase that is key for health and disease.
Indexed as
ChemokinesChild DevelopmentCohort StudiesCytokinesGambiaGene Expression ProfilingHumansImmunophenotypingInfant, NewbornMetabolomicsPapua New GuineaProteomicsSystems BiologyChemokinesCytokines
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.