Evidence map›Paper›PMID 30862746›Full record

ArticlemBio2019

RstA Is a Major Regulator of Clostridioides difficile Toxin Production and Motility.

Adrianne N Edwards, Brandon R Anjuwon-Foster, Shonna M McBride

Open access · goldAbstract read
In one paragraph

Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Characterization of a hypersporulating strain derivativebioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. International journal of molecular sciences · 2024
    Review
  10. Glycine fermentation byInfection and immunity · 2023
    Article
  11. Review
  12. Regulatory transcription factors ofCritical reviews in microbiology · 2023
    Review
  13. Article
  14. Article
  15. Low-toxinEmerging microbes & infections · 2022
    Article
  16. Emerging microbes & infections · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Adrianne N EdwardsDepartment of Microbiology and Immunology, Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia, USA.
Brandon R Anjuwon-FosterDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
Shonna M McBrideDepartment of Microbiology and Immunology, Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia, USA shonna.mcbride@emory.edu.ORCID 0000-0001-6221-714X
Emory University · USUniversity of North Carolina at Chapel Hill · US

Funding

Host-induced Initiation of Clostridium difficile SporulationR01AI116933 · NIAID · EMORY UNIVERSITY · PI SHONNA M. MCBRIDE · 2015 to 2026
$4.8M
Regulation of Clostridium difficile Colonization FactorsR01AI107029 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TAMAYO, RITA · 2013 to 2022
$3.9M
Polymeric Agents for the Treatment of Clostridium difficile InfectionsR33AI121684 · NIAID · EMORY UNIVERSITY · PI GELLMAN, SAMUEL H., MCBRIDE, SHONNA M. · 2018 to 2020
$1.4M
Phase variation of virulence factors in Clostridioides difficileR37AI107029 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RITA TAMAYO · 2025 to 2026
$1.0M
Polymeric Agents for the Treatment of Clostridium difficile InfectionsR21AI121684 · NIAID · EMORY UNIVERSITY · PI GELLMAN, SAMUEL H., MCBRIDE, SHONNA M. · 2016 to 2017
$415k
Phase Variation of Clostridium difficile Flagella and Toxin ProductionF31AI120613 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ANJUWON-FOSTER, BRANDON · 2015 to 2016
$62k
NIAID NIH HHS F31 AI120613NIAID NIH HHS R01 AI107029NIAID NIH HHS R01 AI116933NIAID NIH HHS R21 AI121684NIAID NIH HHS R33 AI121684NIAID NIH HHS R37 AI107029
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene Expression Regulation, BacterialLocomotionBacterial ProteinsBacterial ToxinsClostridioides difficileClostridium perfringensDNA, BacterialDNA-Binding ProteinsDNA Mutational AnalysisEnterotoxinsGenetic Complementation TestMutant ProteinsPromoter Regions, GeneticProtein BindingRepressor ProteinsBacterial ProteinsBacterial ToxinsDNA, BacterialDNA-Binding ProteinsEnterotoxinsMutant ProteinsRepressor ProteinstcdA protein, Clostridium difficiletoxB protein, Clostridium difficileClostridiumClostridium difficilehelix-turn-helixmotilityRNPPRRNPPsporesporulationTcdATcdBtoxintranscriptional regulator

Identifiers

PMID30862746
PMCPMC6414698
OpenAlexW2949908886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.