Evidence map›Paper›PMID 30862736›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Transcriptional factor ATF3 protects against colitis by regulating follicular helper T cells in Peyer's patches.

Yingjiao Cao, Qiong Yang, Hui Deng, Jinyi Tang, Jiancong Hu, Huanliang Liu, Min Zhi, Linsen Ye, Bin Zou, Yongdong Liu and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  9. Review
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  15. Critical regulation of follicular helper T cell differentiation and function by GαProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  16. Review
  17. Article
  18. Observational
  19. ATF3 Prevents Stress-Induced Hematopoietic Stem Cell Exhaustion.Frontiers in cell and developmental biology · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Yingjiao CaoJoint Program in Immunology, Department of Internal Medicine, Affiliated Guangzhou Women and Children's Medical Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510623, China.
Qiong YangInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Hui DengJoint Program in Immunology, Department of Internal Medicine, Affiliated Guangzhou Women and Children's Medical Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510623, China.
Jinyi TangCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
Jiancong HuDepartment of Clinical Laboratory, Gastroenterology, and Colorectal Surgery, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.
Huanliang LiuDepartment of Clinical Laboratory, Gastroenterology, and Colorectal Surgery, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.
Min ZhiDepartment of Clinical Laboratory, Gastroenterology, and Colorectal Surgery, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.
Linsen YeDepartment of Hepatic Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China.
Bin ZouState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
Yongdong LiuDepartment of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China 510080.
Lai WeiState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.ORCID 0000-0002-3300-8506
Dmitry I GabrilovichInstitute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Haikun WangCAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
Jie ZhouJoint Program in Immunology, Department of Internal Medicine, Affiliated Guangzhou Women and Children's Medical Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510623, China; zhoujie@tmu.edu.cn.ORCID 0000-0001-5964-1599
Sun Yat-sen University · CNChinese Academy of Sciences · CNThe Wistar Institute · US

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
NCI NIH HHS P30 CA010815
6 · The paper itself

Abstract

Disruption of mucosal immunity plays a critical role in the pathogenesis of inflammatory bowel disease, yet its mechanism remains not fully elucidated. Here, we found that activating transcription factor 3 (ATF3) protects against colitis by regulating follicular helper T (T

Indexed as

Activating Transcription Factor 3Adoptive TransferAnimalsB-LymphocytesCD4-Positive T-LymphocytesColitisColitis, UlcerativeColonDextran SulfateDisease Models, AnimalGene Expression ProfilingHomeostasisImmunity, MucosalImmunoglobulin AImmunotherapyMiceActivating Transcription Factor 3Atf3 protein, mouseDextran SulfateImmunoglobulin Aactivating transcription factor 3colitisfollicular helper T cellintestinal mucosal immunityPeyer’s patches

Identifiers

PMID30862736
PMCPMC6442638
OpenAlexW2921526104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.