Evidence map›Paper›PMID 30862712›Full record

ArticleThe Journal of general physiology2019

Ano1 mediates pressure-sensitive contraction frequency changes in mouse lymphatic collecting vessels.

Scott D Zawieja, Jorge A Castorena, Peichun Gui, Min Li, Simon A Bulley, Jonathan H Jaggar, Jason R Rock, Michael J Davis

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of general physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 72 citations in OpenAlex.

  1. Pacemaking in the lymphatic system.The Journal of physiology · 2026
    Review
  2. Review
  3. Review
  4. The Function ofbioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Role of ANO1 CaPflugers Archiv : European journal of physiology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Role of Sensory Nerves in Pulmonary Fibrosis.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Scott D ZawiejaDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO.
Jorge A CastorenaDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO.
Peichun GuiDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO.
Min LiDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO.
Simon A BulleyDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN davismj@health.missouri.edu.
Jonathan H JaggarDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN.ORCID 0000-0003-1505-3335
Jason R RockDepartment of Medicine, Boston University School of Medicine, Boston, MA.
Michael J DavisDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO davismj@health.missouri.edu.ORCID 0000-0002-7992-9300
University of Missouri · USUniversity of Tennessee Health Science Center · USBoston University · US

Funding

Lymphatic pacemaking and pumping in lymphedema: function, dysfunction, and rescueR01HL122578 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI DAVIS, MICHAEL JOHN · 2015 to 2023
$4.1M
Endothelial cell potassium channelsR01HL137745 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JAGGAR, JONATHAN H · 2017 to 2020
$2.0M
Conduction and coordination of electrical signals within the lymphatic vascular wallR01HL125608 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI DAVIS, MICHAEL JOHN · 2015 to 2018
$1.6M
Blood pressure regulation by smooth muscle cell ion channelsR01HL133256 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JAGGAR, JONATHAN H · 2017 to 2020
$1.5M
KATP channels and lymphatic dysfunction in Cantu SyndromeR01HL141107 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI DAVIS, MICHAEL JOHN · 2018 to 2021
$1.5M
The Regulation of Lymphatic Muscle Cell Pacemaking by Intracellular Calcium SignalsK99HL143198 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI ZAWIEJA, SCOTT D. · 2019 to 2020
$203k
NHLBI NIH HHS K99 HL143198NHLBI NIH HHS R01 HL122578NHLBI NIH HHS R01 HL125608NHLBI NIH HHS R01 HL133256NHLBI NIH HHS R01 HL137745NHLBI NIH HHS R01 HL141107
6 · The paper itself

Abstract

Lymphatic collecting vessels exhibit spontaneous contractions with a pressure-dependent contraction frequency. The initiation of contraction has been proposed to be mediated by the activity of a Ca

Indexed as

AnimalsAnoctamin-1BenzbromaroneCalciumGene Expression RegulationLymphatic VesselsMaleMembrane PotentialsMiceMice, TransgenicPressureProtein ConformationUricosuric AgentsANO1 protein, mouseAnoctamin-1BenzbromaroneCalciumUricosuric Agents

Identifiers

PMID30862712
PMCPMC6445586
OpenAlexW2921585179

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.