Evidence map›Paper›PMID 30862663›Full record

SynthesisEMBO molecular medicine2019

Cellular, molecular, and clinical mechanisms of action of deep brain stimulation-a systematic review on established indications and outlook on future developments.

Martin Jakobs, Anton Fomenko, Andres M Lozano, Karl L Kiening

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in EMBO molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Invasive and Non-invasive Neurostimulation for OCD.Current topics in behavioral neurosciences · 2021
    Pooled it
  4. Pooled it
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  12. Review
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  17. Prefrontal Network Mechanisms of Psychiatric Deep Brain Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  18. Review
  19. Review
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Martin JakobsDepartment of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany martin.jakobs@med.uni-heidelberg.de.ORCID 0000-0002-6104-8898
Anton FomenkoDivision of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.ORCID 0000-0003-4131-6784
Andres M LozanoDivision of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Karl L KieningDepartment of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep brain stimulation (DBS) has been successfully used to treat movement disorders, such as Parkinson's disease, for more than 25 years and heralded the advent of electrical neuromodulation to treat diseases with dysregulated neuronal circuits. DBS is now superseding ablative techniques, such as stereotactic radiofrequency lesions. While serendipity has played a role in developing DBS as a therapy, research during the past two decades has shown that electrical neuromodulation is far more than a functional lesion that can be switched on and off. This understanding broadens the field to enable new types of stimulation, clinical indications, and research. This review highlights the complex effects of DBS from the single cell to the neuronal network. Specifically, we examine the electrical, cellular, molecular, and neurochemical mechanisms of DBS as applied to Parkinson's disease and other emerging applications.

Indexed as

Deep Brain StimulationAnimalsBrainElectricityEpigenesis, GeneticHumansNeurogenesisNeuronal PlasticityNeuronsParkinson Diseasecircuitopathiesdeep brain stimulationmovement disordersneuromodulationParkinson's disease

Identifiers

PMID30862663
PMCPMC6460356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.