Evidence map›Paper›PMID 30862473›Full record

ArticleMolecular metabolism2019

Perm1 regulates CaMKII activation and shapes skeletal muscle responses to endurance exercise training.

Yoshitake Cho, Shizuko Tachibana, Bethany C Hazen, James J Moresco, John R Yates, Bernard Kok, Enrique Saez, Robert S Ross, Aaron P Russell, Anastasia Kralli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
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  5. Review
  6. Article
  7. NOR-1 Overexpression Elevates Myoglobin Expression via PERM1 and Enhances Mitochondrial Function and Endurance in Skeletal Muscles of Aged Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  8. PERM1 regulates mitochondrial energetics through O-GlcNAcylation in the heart.Journal of molecular and cellular cardiology · 2025
    Article
  9. Article
  10. Review
  11. Cardiac maturation.Journal of molecular and cellular cardiology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Yoshitake ChoDepartment of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, 92037, USA; Division of Cardiology, Department of Medicine, University of California San Diego, La Jolla, CA, 92093, USA. Electronic address: cyoshitake@ucsd.edu.
Shizuko TachibanaDepartment of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, 92037, USA; Division of Cardiology, Department of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Bethany C HazenDepartment of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
James J MorescoDepartment of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, 92037, USA; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA.
John R YatesDepartment of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, 92037, USA; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Bernard KokDepartment of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, 92037, USA; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Enrique SaezDepartment of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, 92037, USA; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Robert S RossDivision of Cardiology, Department of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
Aaron P RussellInstitute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.
Anastasia KralliDepartment of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, 92037, USA; Department of Physiology, Johns Hopkins University, Baltimore, MD, 21205, USA. Electronic address: akralli1@jhmi.edu.
Scripps Research Institute · USUniversity of California, San Diego · USDeakin University · AUJohns Hopkins University · US

Funding

Estrogen-Related Receptor Pathways in Skeletal MuscleR01DK105126 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI KRALLI, ANASTASIA · 2015 to 2019
$1.9M
NIDDK NIH HHS R01 DK105126
6 · The paper itself

Abstract

objectiveEndurance exercise training remodels skeletal muscle, leading to increased mitochondrial content and oxidative capacity. How exercise entrains skeletal muscle signaling pathways to induce adaptive responses remains unclear. In past studies, we identified Perm1 (PGC-1 and ERR induced regulator, muscle 1) as an exercise-induced gene and showed that Perm1 overexpression elicits similar muscle adaptations as endurance exercise training. The mechanism of action and the role of Perm1 in exercise-induced responses are not known. In this study, we aimed to determine the pathway by which Perm1 acts as well as the importance of Perm1 for acute and long-term responses to exercise.

methodsWe performed immunoprecipitation and mass spectrometry to identify Perm1 associated proteins, and validated Perm1 interactions with the Ca

resultsWe show that Perm1 associates with skeletal muscle CaMKII and promotes CaMKII activation. In response to an acute exercise bout, muscles with a knock down of Perm1 showed defects in the activation of CaMKII and p38 MAPK and blunted induction of regulators of oxidative metabolism. Following four weeks of voluntary training, Perm1 knockdown muscles had attenuated mitochondrial biogenesis. Finally, we found that Perm1 expression is reduced in diet-induced obese mice and in muscular dystrophy patients and mouse models.

conclusionsOur findings identify Perm1 as a muscle-specific regulator of exercise-induced signaling and Perm1 levels as tuners of the skeletal muscle response to exercise. The decreased Perm1 levels in states of obesity or muscle disease suggest that Perm1 may link pathological states to inefficient exercise responses.

Indexed as

Endurance TrainingPhysical Conditioning, AnimalAdolescentAdultAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Cell Line, TumorChildChild, PreschoolExercise TestFemaleGene Knockdown TechniquesHEK293 CellsHumansInfantMaleCalcium-Calmodulin-Dependent Protein Kinase Type 2Muscle ProteinsPERM1 protein, mouseCaMKII signalingEndurance exercise trainingMitochondrial biogenesisp38 MAPK regulationSkeletal muscle

Identifiers

PMID30862473
PMCPMC6480336
OpenAlexW2920791138

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.