ArticlePsychological medicine2020
Neuropsychological deficits in participants at clinical high risk for psychosis recruited from the community: relationships to functioning and clinical symptoms.
Article in Psychological medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Processing Speed and Verbal Learning Ability as Predictors of Assessor-Rated and Ecological Momentary Assessment Self-Reported Functioning: Findings from AMP SCZ.Schizophrenia bulletin · 2026Article
- Cognitive trajectories of psychosis risk: temporal patterns and association with progression.Molecular psychiatry · 2026Article
- Impairments in biological motion perception reflect affective disturbance in individuals at clinical high-risk for psychosis.Schizophrenia research. Cognition · 2026Article
- Temporal integration window of sensory processing as a neuropsychological marker for clinical high risk of psychosis.Schizophrenia (Heidelberg, Germany) · 2025Article
- Timeframe for Conversion to Psychosis From Individuals at Clinical High-Risk: A Quantile Regression.Schizophrenia bulletin · 2025Article
- Neurocognitive resilience as a predictor of psychosis onset and functional outcomes in individuals at high risk.BMC medicine · 2025Article
- Face and emotion recognition in individuals diagnosed with schizophrenia, ultra-high risk for psychosis, unaffected siblings, and healthy controls in a sample from Turkey.Schizophrenia research. Cognition · 2024Article
- Clinical and Functional Outcomes of Community-Recruited Individuals at Clinical High-Risk for Psychosis: Results From the Youth Mental Health Risk and Resilience Study (YouR-Study).Schizophrenia bulletin open · 2024Article
- Clinical high risk for psychosis syndrome is associated with reduced neural responding to unpleasant images.Journal of psychopathology and clinical science · 2023Article
- Investigating temporal and prosodic markers in clinical high-risk for psychosis participants using automated acoustic analysis.Early intervention in psychiatry · 2023Article
- The association between mental health stigma and face emotion recognition in individuals at risk for psychosis.Stigma and health · 2023Article
- TSP-GNN: a novel neuropsychiatric disorder classification framework based on task-specific prior knowledge and graph neural network.Frontiers in neuroscience · 2023Article
- Comparing a Computerized Digit Symbol Test to a Pen-and-Paper Classic.Schizophrenia bulletin open · 2023Article
- Characterising cognitive heterogeneity in individuals at clinical high-risk for psychosis: a cluster analysis with clinical and functional outcome prediction.European archives of psychiatry and clinical neuroscience · 2022Article
- Cognitive predictors of longitudinal positive symptom course in clinical high risk for psychosis.Schizophrenia research. Cognition · 2021Article
- Prevalence of Individuals at Clinical High-Risk of Psychosis in the General Population and Clinical Samples: Systematic Review and Meta-Analysis.Brain sciences · 2021Review
- Duration of basic and attenuated-psychotic symptoms in individuals at clinical high risk for psychosis: pattern of symptom onset and effects of duration on functioning and cognition.BMC psychiatry · 2021Article
- Smoking Is Related to Reduced Motivation, But Not Global Cognition, in the First Two Years of Treatment for First Episode Psychosis.Journal of clinical medicine · 2021Article
- Neurocognitive Impairment in Severe Mental Illness. Comparative study with Spanish Speaking Patients.Brain sciences · 2021Article
- Computerized Assessment of Psychosis Risk.Journal of psychiatry and brain science · 2021Article
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Authors and funding
10 authors.
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Abstract
backgroundThe current study examined the pattern of neurocognitive impairments in a community-recruited sample of clinical high-risk (CHR) participants and established relationships with psychosocial functioning.
methodsCHR-participants (n = 108), participants who did not fulfil CHR-criteria (CHR-negatives) (n = 42) as well as a group of healthy controls (HCs) (n = 55) were recruited. CHR-status was assessed using the Comprehensive Assessment of At-Risk Mental States (CAARMS) and the Schizophrenia Proneness Instrument, Adult Version (SPI-A). The Brief Assessment of Cognition in Schizophrenia Battery (BACS) as well as tests for emotion recognition, working memory and attention were administered. In addition, role and social functioning as well as premorbid adjustment were assessed.
resultsCHR-participants were significantly impaired on the Symbol-Coding and Token-Motor task and showed a reduction in total BACS-scores. Moreover, CHR-participants were characterised by prolonged response times (RTs) in emotion recognition as well as by reductions in both social and role functioning, GAF and premorbid adjustments compared with HCs. Neurocognitive impairments in emotion recognition accuracy, emotion recognition RT, processing speed and motor speed were associated with several aspects of functioning explaining between 4% and 12% of the variance.
conclusionThe current data obtained from a community sample of CHR-participants highlight the importance of dysfunctions in motor and processing speed and emotion recognition RT. Moreover, these deficits were found to be related to global, social and role functioning, suggesting that neurocognitive impairments are an important aspect of sub-threshold psychotic experiences and a possible target for therapeutic interventions.
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