Evidence map›Paper›PMID 30862283›Full record

ArticleJournal of the Royal Society, Interface2019

Epicardial prestrained confinement and residual stresses: a newly observed heart ventricle confinement interface.

Xiaodan Shi, Yue Liu, Katherine M Copeland, Sara R McMahan, Song Zhang, J Ryan Butler, Yi Hong, Michael Cho, Pietro Bajona, Huajian Gao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Royal Society, Interface, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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  9. Review
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  11. Current advances in biodegradable synthetic polymer based cardiac patches.Journal of biomedical materials research. Part A · 2020
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaodan Shi1 Department of Bioengineering, University of Texas at Arlington , Arlington, TX 76010 , USA.
Yue Liu2 School of Engineering, Brown University , Providence, RI 02912 , USA.
Katherine M Copeland1 Department of Bioengineering, University of Texas at Arlington , Arlington, TX 76010 , USA.
Sara R McMahan1 Department of Bioengineering, University of Texas at Arlington , Arlington, TX 76010 , USA.
Song Zhang3 Bagley College of Engineering, College of Veterinary Medicine, Mississippi State University , Mississippi State, MS 39762 , USA.
J Ryan Butler3 Bagley College of Engineering, College of Veterinary Medicine, Mississippi State University , Mississippi State, MS 39762 , USA.
Yi Hong1 Department of Bioengineering, University of Texas at Arlington , Arlington, TX 76010 , USA.
Michael Cho1 Department of Bioengineering, University of Texas at Arlington , Arlington, TX 76010 , USA.
Pietro Bajona4 Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center , Dallas, TX 75390 , USA.
Huajian Gao2 School of Engineering, Brown University , Providence, RI 02912 , USA.
Jun Liao1 Department of Bioengineering, University of Texas at Arlington , Arlington, TX 76010 , USA.

Funding

CONTROL OF CARDIAC FIBROSIS TO PREVENT CARDIAC FUNCTION DETERIORATIONR01EB022018 · NIBIB · WASHINGTON UNIVERSITY · PI GUAN, JIANJUN · 2016 to 2018
$1.1M
NIBIB NIH HHS R01 EB022018
6 · The paper itself

Abstract

The heart epicardial layer, with elastin as the dominant component, has not been well investigated, specifically on how it contributes to ventricular biomechanics. In this study, we revealed and quantitatively assessed the overall status of prestraining and residual stresses exerted by the epicardial layer on the heart left ventricle (LV). During porcine heart wall dissection, we discovered that bi-layered LV surface strips, consisting of an epicardial layer and cardiac muscle, always curled towards the epicardial side due to epicardial residual stresses. We hence developed a curling angle characterization technique to intuitively and qualitatively reveal the location-dependency and direction-dependency of epicardial residual stresses. Moreover, by combining prestrain measurement and biaxial mechanical testing, we were able to quantify the epicardial prestrains and residual stresses on the unpressurized intact LV. To investigate the potential mechanical effect of epicardial prestraining, a finite-element (FE) model has been constructed, and we demonstrate that it is the prestraining of the epicardial layer, not the epicardial layer alone, providing an additional resistance mechanism during LV diastolic expansion and ventricular wall protection by reducing myocardial stress. In short, our study on healthy, native porcine hearts has revealed an important phenomenon-the epicardial layer, rich in elastin, acts like a prestrained 'balloon' that wraps around the heart and functions as an extra confinement and protection interface. The obtained knowledge fills a gap in ventricular biomechanics and will help design novel biomimicking materials or prosthetic devices to target the maintenance/recreation of this ventricle confinement interface.

Indexed as

Heart VentriclesModels, CardiovascularMyocardiumStress, MechanicalVentricular FunctionAnimalsMyocardial ContractionPericardiumSwinecardiac elastinepicardial layerepicardial prestrainingepicardial residual stressheartventricle confinement interface

Identifiers

PMID30862283
PMCPMC6451409

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.