Evidence map›Paper›PMID 30862271›Full record

ArticleThe Journal of international medical research2019

Identification of key pathways regulated by a set of competitive long non-coding RNAs in oral squamous cell carcinoma.

Zhifeng Yang, Zili Liu, Lingqiu Meng, Shuyan Ma

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Zhifeng YangDepartment of Stomatology, The Second People's Hospital of Liaocheng, Shandong Province, P. R. China.ORCID https://orcid.org/0000-0003-3056-2787
Zili LiuDepartment of Stomatology, The Second People's Hospital of Liaocheng, Shandong Province, P. R. China.
Lingqiu MengDepartment of Stomatology, The Second People's Hospital of Liaocheng, Shandong Province, P. R. China.
Shuyan MaDepartment of Stomatology, The Second People's Hospital of Liaocheng, Shandong Province, P. R. China.
Fourth People's Hospital of Liaocheng · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to identify important pathways regulated by a set of long non-coding RNAs (lncRNAs) in oral squamous cell carcinoma (OSCC).

methodsA lncRNA-mediated competitive endogenous RNA network (LMCN) was constructed using information on microRNA (miRNA)-mRNA interactions and lncRNA-miRNA intersections from the E-GEOD-37991 transcription profiling data in the ArrayExpress database. A random walk with restart ranking algorithm was then applied to evaluate the influences of protein-coding genes regulated by competitive lncRNAs. Pathway enrichment scores were calculated based on the propagation scores of protein-coding genes. Finally, permutation tests were used to estimate the significance of the pathways.

resultsWe obtained lncRNA-mRNA interactions based on miRNAs common to both miRNA-mRNA interactions and lncRNA-miRNA intersections, and used interactions with a z-score > 0.7 to construct a LMCN. Ten lncRNAs were identified as source nodes in the LMCN, and nine pathways with enrichment scores >0.8, including 'Cell cycle', 'Endocytosis', and 'Pathways in cancer', were significantly enriched by these source nodes.

conclusionsNine significant pathways regulated by a set of competitive lncRNAs were identified in OSCC, which may play important roles in the development of OSCC via the cell cycle and endocytosis.

Indexed as

Gene Expression Regulation, NeoplasticGene Regulatory NetworksBiomarkers, TumorCarcinoma, Squamous CellGene Expression ProfilingHumansMicroRNAsMouth NeoplasmsRNA, Long NoncodingRNA, MessengerBiomarkers, TumorMicroRNAsRNA, Long NoncodingRNA, Messengercell cycleendocytosislncRNAnetworkoral squamous cell carcinomapathway

Identifiers

PMID30862271
PMCPMC6460590
OpenAlexW2921723100

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.