ArticleMaterials (Basel, Switzerland)2019
Monodisperse Fe₃O₄/SiO₂ and Fe₃O₄/SiO₂/PPy Core-Shell Composite Nanospheres for IBU Loading and Release.
Article in Materials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 27 citations in OpenAlex.
- Design and application of a magnetically recoverable citric acid-functionalized graphene oxide nanocomposite for ultrasound-assisted green synthesis of naphthopyrimidines.Scientific reports · 2026Article
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- Facile Synthesis of Hollow FeNanomaterials (Basel, Switzerland) · 2023Article
- Comparison of the Surface Properties of Hydrothermally Synthesised FeNanomaterials (Basel, Switzerland) · 2021Article
- Silica-Coated FeTechnology in cancer research & treatmentArticle
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4 authors at 2 institutions in 1 country.
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Abstract
The magnetic targeting drug delivery system is an effective way of targeting therapy. In this study, the monodisperse Fe₃O₄ nanoparticles with a particles size of about 180 nm were first prepared via a solvothermal method. Subsequently, the core-shell structure Fe₃O₄/SiO₂ and Fe₃O₄/SiO₂/polypyrrole (PPy) composite nanospheres were successfully synthesized by coating Fe₃O₄ nanoparticles with SiO₂ shell layer using the Stöber method and PPy shell by solvothermal method in turn. The as-prepared nanoparticles were characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FT-IR), vibrating sample magnetometer (VSM), thermogravimetric analysis (TGA), and Ultraviolet-Visible spectrophotometer (UV-Vis). The results indicated that the as-prepared composite nanospheres displayed a well-defined core-shell structure and monodispersity. The thicknesses of SiO₂ shell and PPy shell were ~6 nm and ~19 nm, respectively. Additionally, the as-prepared nanoparticles exhibited high saturation magnetization of 104 emu/g, 77 emu/g, and 24 emu/g, and have great potential applications in drug delivery. The drug loading and drug release of the Fe₃O₄/SiO₂ and Fe₃O₄/SiO₂/PPy composite nanospheres to ibuprofen (IBU) under stirring and ultrasonication were investigated. Their drug loading efficiency and drug release efficiency under ultrasonication were all higher than 33% and 90%, respectively. The drug release analyses showed sustained release of IBU from nanospheres and followed the Korsmeyer-Peppas model.
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