ArticleBrain pathology (Zurich, Switzerland)2019
Neuropathological lesions in the very old: results from a large Brazilian autopsy study.
Article in Brain pathology (Zurich, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Sex differences in dementia pathology and cognitive performance in a population-based, ethnically diverse Brazilian autopsy study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The past, present, and future of Alzheimer's disease-part 3: the future.Arquivos de neuro-psiquiatria · 2026Review
- Sex Differences in Amyloid Pathology by Race, Ancestry, and Apolipoprotein E ε4 in an Admixed Autopsy Sample.JAMA neurology · 2026Article
- The prevalence of Lewy body pathology across nine international community-based cohorts.Brain : a journal of neurology · 2026Article
- Associations of pathologic Parkinson's disease (PD) and co-pathologies with cognitive decline and progression of parkinsonian signs in decedents with subclinical disease.Acta neuropathologica · 2025Article
- Apolipoprotein E and Alzheimer's disease pathology in a diverse autopsy study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Lewy Body Dementia Research in Latin America: A Scoping Review.Movement disorders clinical practice · 2025Article
- Pure LATE-NC: Frequency, clinical impact, and the importance of considering APOE genotype when assessing this and other subtypes of non-Alzheimer's pathologies.Acta neuropathologica · 2024Article
- Neuropathological Lesions and Cognitive Abilities in Black and White Older Adults in Brazil.JAMA network open · 2024Article
- Alzheimer's disease: part 2 - the present.Arquivos de neuro-psiquiatria · 2024Review
- Is Alzheimer disease a disease?Nature reviews. Neurology · 2024Review
- Identifying individuals with non-Alzheimer's disease co-pathologies: A precision medicine approach to clinical trials in sporadic Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Cerebral Small Vessel Disease, Hypertension, and Vascular Contributions to Cognitive Impairment and Dementia.Hypertension (Dallas, Tex. : 1979) · 2024Review
- Study of neuropathological changes and dementia in 100 centenarians in The 90+ Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Global and local ancestry modulate APOE association with Alzheimer's neuropathology and cognitive outcomes in an admixed sample.Molecular psychiatry · 2022Article
- Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts.Acta neuropathologica · 2022Article
- Brain arteriolosclerosis.Acta neuropathologica · 2021Review
- Language and spatial dysfunction in Alzheimer disease with white matter thorn-shaped astrocytes.Neurology · 2020Article
- Response letter: neuropathological lesions in the very old.Brain pathology (Zurich, Switzerland) · 2020Article
- Anthropometric rather than ethnic factors may explain differences in the incidence of Alzheimer-type neurodegenerative changes.Brain pathology (Zurich, Switzerland) · 2020Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveTo compare neuropathological correlates of cognitive impairment between very old and younger individuals from a Brazilian clinicopathological study.
methodsWe assessed the frequency of neuropathological lesions and their association with cognitive impairment (Clinical Dementia Rating scale ≥0.5) in the 80 or over age group compared to younger participants, using logistic regression models adjusted for sex, race and education.
resultsExcept for infarcts and siderocalcinosis, all neuropathological lesions were more common in the 80 or over age group (n = 412) compared to 50-79 year olds (n = 677). Very old participants had more than twice the likelihood of having ≥2 neuropathological diagnoses than younger participants (OR = 2.66, 95% CI = 2.03-3.50). Neurofibrillary tangles, infarcts and hyaline arteriolosclerosis were associated with cognitive impairment in the two age groups. Siderocalcinosis was associated with cognitive impairment in the younger participants only, while Lewy body disease was associated with cognitive impairment in the very old only. In addition, we found that the association of infarcts and multiple pathologies with cognitive impairment was attenuated in very old adults (Infarcts: P for interaction = 0.04; and multiple pathologies: P = 0.05). However, the predictive value for the aggregate model with all neuropathological lesions showed similar discrimination in both age groups [Area under Receiver Operating Characteristic curve (AUROC) = 0.778 in younger participants and AUROC = 0.765 in the very old]. CONCLUSION AND RELEVANCE: Despite a higher frequency of neuropathological findings in the very old group, as found in studies with high-income populations, we found attenuation of the effect of infarcts rather than neurofibrillary tangles and plaques as reported previously.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.