Evidence map›Paper›PMID 30861530›Full record

ArticlePain medicine (Malden, Mass.)2019

Antidepressant Use Among People Prescribed Opioids for Chronic Noncancer Pain.

Natasa Gisev, Suzanne Nielsen, Gabrielle Campbell, Thomas Santo, Andrea Mant, Raimondo Bruno, Milton Cohen, Wayne D Hall, Briony Larance, Nicholas Lintzeris and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain medicine (Malden, Mass.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Observational evidence linking psychotropic medicines to the dispensing of opioid agents in later life.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2024
    Observational
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Mechanisms for Reducing Neuropathic Pain.Molecular neurobiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Natasa GisevNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, New South Wales, Australia.
Suzanne NielsenNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, New South Wales, Australia.
Gabrielle CampbellNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, New South Wales, Australia.
Thomas SantoNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, New South Wales, Australia.
Andrea MantNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, New South Wales, Australia.
Raimondo BrunoSchool of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
Milton CohenSt Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, New South Wales, Australia.
Wayne D HallCentre for Youth Substance Abuse Research, University of Queensland, Brisbane, Queensland, Australia.
Briony LaranceNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, New South Wales, Australia.
Nicholas LintzerisDiscipline of Addiction Medicine, The University of Sydney, Sydney, New South Wales, Australia.
Michael FarrellNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, New South Wales, Australia.
Louisa DegenhardtNational Drug and Alcohol Research Centre, UNSW Sydney, Sydney, New South Wales, Australia.

Funding

Using existing data to understand and ameliorate risk in opioid agonist therapyR01DA044170 · NIDA · UNIVERSITY OF NEW SOUTH WALES · PI DEGENHARDT, LOUISA · 2017 to 2019
$641k
NIDA NIH HHS R01 DA044170
6 · The paper itself

Abstract

objectiveAlthough depression and chronic pain often coexist, few studies have examined antidepressant use among people with pain. This study examines the prevalence and characteristics associated with antidepressant use among people prescribed opioids for chronic noncancer pain (CNCP).

designBaseline data from a prospective cohort study.

settingAustralian community. SUBJECTS: A total of 1166 people prescribed opioids for CNCP.

methodsBaseline data collection consisted of a self-completed seven-day medication diary and telephone interview to collect information on sociodemographic characteristics and mental/physical health using validated questionnaires. Logistic regression was used to examine characteristics associated with antidepressant use, reporting adjusted odds ratios (AORs) and 95% confidence intervals (CIs).

resultsOf the 1166 participants, 668 (57.3%) were female, and the median (interquartile range) age was 59 (49-68) years. About half the cohort (N = 637, 54.6%) used antidepressants. Of these, 329 (51.7%) reported moderate to severe depression. Amitriptyline was the most commonly used antidepressant (17.3%). Factors independently associated with antidepressant use were being female (AOR = 1.47, 95% CI = 1.13-1.92), more years lived in pain (AOR = 1.01, 95% CI = 1.00-1.02), and use of nonopioid analgesics (AOR = 1.34, 95% CI = 1.01-1.78), benzodiazepines and related drugs (AOR = 1.84, 95% CI = 1.36-2.49), antiepileptics (AOR = 1.86, 95% CI = 1.38-2.51), and antipsychotics (AOR = 2.15, 95% CI = 1.22-3.77).

conclusionsAntidepressant use is common among people with CNCP prescribed opioids. Those using antidepressants were more likely to use other psychotropic medicines concurrently, highlighting that they are a high-risk population requiring comprehensive assessment to optimize outcomes and reduce potential harms from polypharmacy.

Indexed as

AgedAnalgesics, Non-NarcoticAnalgesics, OpioidAnticonvulsantsAntidepressive AgentsAntipsychotic AgentsBenzodiazepinesChronic PainCohort StudiesDepressive DisorderFemaleHumansMaleMiddle AgedOdds RatioPolypharmacyAnalgesics, Non-NarcoticAnalgesics, OpioidAnticonvulsantsAntidepressive AgentsAntipsychotic AgentsBenzodiazepinesAntidepressantsChronic PainDrug Utilization(MeSH): AnalgesicsOpioids

Identifiers

PMID30861530
PMCPMC7963210

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.