Evidence map›Paper›PMID 30861526›Full record

ReviewInternational archives of allergy and immunology

Functional Role of MicroRNAs in Thymocyte Development.

Lin Hu, Ling Mao, Shiming Liu, Juanjuan Zhao, Chao Chen, Mengmeng Guo, Zhixu He, Jie Yang, Wei Xu, Lin Xu

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International archives of allergy and immunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Lin HuSpecial Key Laboratory of Gene Detection and Therapy of the Guizhou Province, Zunyi Medical University, Zunyi, China.
Ling MaoSpecial Key Laboratory of Gene Detection and Therapy of the Guizhou Province, Zunyi Medical University, Zunyi, China.
Shiming LiuSpecial Key Laboratory of Gene Detection and Therapy of the Guizhou Province, Zunyi Medical University, Zunyi, China.
Juanjuan ZhaoSpecial Key Laboratory of Gene Detection and Therapy of the Guizhou Province, Zunyi Medical University, Zunyi, China.
Chao ChenSpecial Key Laboratory of Gene Detection and Therapy of the Guizhou Province, Zunyi Medical University, Zunyi, China.
Mengmeng GuoSpecial Key Laboratory of Gene Detection and Therapy of the Guizhou Province, Zunyi Medical University, Zunyi, China.
Zhixu HeStem Cell and Tissue Engineering Research Center, Guizhou Medical University, Guiyang, China.
Jie YangJiangsu Provincial Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Wei XuJiangsu Provincial Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China.
Lin XuSpecial Key Laboratory of Gene Detection and Therapy of the Guizhou Province, Zunyi Medical University, Zunyi, China, xulinzhouya@163.com.
Zunyi Medical University · CNSoochow University · CNGuiyang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are a class of endogenous noncoding single-stranded RNAs widely distributed in eukaryotes, which can modulate target gene expression at posttranscriptional level and participate in cell proliferation, differentiation, and apoptosis. Related studies have shown that mi-RNAs are instrumental to many aspects of immunity, including various levels of T-cell immunity. In addition, multiple miRNAs have been ascribed key roles in T-cell development, differentiation, and function. In this review, we highlight the current literature regarding the functional role of miRNAs at various stages of thymocyte development. A better understanding of the relationship between miRNAs and thymocyte development is helpful for the exploration of the exact roles of miRNAs in the development and function of the immune system, as well as related clinical diseases.

Indexed as

AnimalsHumansMicroRNAsNatural Killer T-CellsReceptors, Antigen, T-CellThymocytesMicroRNAsReceptors, Antigen, T-CellDevelopmentmiRNAsThymocytes

Identifiers

PMID30861526
PMCPMC6518860
OpenAlexW2925299264

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.