Evidence map›Paper›PMID 30861456›Full record

ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2019

Effects of deuteration on transamination and oxidation of hyperpolarized

Alexander M Funk, Xiaodong Wen, Thomas Hever, Nesmine R Maptue, Chalermchai Khemtong, A D Sherry, Craig R Malloy

Open access · greenAbstract read
In one paragraph

Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Theranostics · 2025
    Article
  2. [6,6'-NMR in biomedicine · 2023
    Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Alexander M FunkAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Xiaodong WenAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Thomas HeverAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Nesmine R MaptueAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Chalermchai KhemtongAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States.
A D SherryAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States; Department of Chemistry, University of Texas at Dallas, Richardson, TX, United States.
Craig R MalloyAdvanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States; Veterans Affairs North Texas Healthcare System, Dallas, TX, United States. Electronic address: Craig.Malloy@UTSouthwestern.edu.
Advanced Imaging Research (United States) · USSouthwestern Medical Center · USThe University of Texas Southwestern Medical Center · US

Funding

TR&D 3: Imaging Carbohydrate MetabolismP41EB015908 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2012 to 2021
$10.9M
Metabolism in the Heart by NMRR37HL034557 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SHERRY, DEAN · 2008 to 2017
$3.9M
INTERMEDIARY METABOLISM IN THE HEART BY NMRR01HL034557 · NHLBI · UNIVERSITY OF TEXAS DALLAS · PI SHERRY, DEAN · 1988 to 2006
$1.9M
NHLBI NIH HHS R01 HL034557NHLBI NIH HHS R37 HL034557NIBIB NIH HHS P41 EB015908
6 · The paper itself

Abstract

This study was designed to determine the effects of deuteration in pyruvate on exchange reactions in alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and flux through pyruvate dehydrogenase (PDH). Although deuteration of a

Indexed as

AlanineAlanine TransaminaseAminationAnimalsCarbon IsotopesDeuteriumIn Vitro TechniquesLactic AcidL-Lactate DehydrogenaseMagnetic Resonance SpectroscopyMyocardiumOxidation-ReductionPyruvate Dehydrogenase ComplexPyruvic AcidRatsRats, Sprague-DawleyAlanineAlanine TransaminaseCarbon IsotopesDeuteriumLactic AcidL-Lactate DehydrogenasePyruvate Dehydrogenase ComplexPyruvic AcidWaterDeuterationHyperpolarizationIsolated heartsIsotopomer analysisKinetic isotope effectsPerfusions

Identifiers

PMID30861456
PMCPMC6666394
OpenAlexW2920193954

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.