Evidence map›Paper›PMID 30861279›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2019

Center-level trends in utilization of HCV-exposed donors for HCV-uninfected kidney and liver transplant recipients in the United States.

Mary G Bowring, Ashton A Shaffer, Allan B Massie, Andrew Cameron, Niraj Desai, Mark Sulkowski, Jacqueline Garonzik-Wang, Dorry L Segev

Registry-linked trialAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07341516 (Worldwide Assessment of Deceased Donor Kidney Utilization), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07341516 enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Worldwide Assessment of Deceased Donor Kidney Utilization: Disparities, Temporal Trends, and Outcomes

TypeobservationalSponsorParis Translational Research Center for Organ TransplantationRan2025 to 2026Enrolled300,000ConditionsKidney Failure, Kidney Transplant, Deceased Donor Kidney Transplant
3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Assessing Tissue Transmission of Hepatitis C Virus From Viremic Donor to Seronegative Kidney Transplant Recipients: A Case Series.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. HCV-Infected Deceased Donor Kidney Transplantation-Time to Take Up the Offer.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2020
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Trends over Time in Practice and Outcomes of Lung Transplantation in Recipients With Human Immunodeficiency Virus.Transplant infectious disease : an official journal of the Transplantation Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mary G BowringDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-7299-7730
Ashton A ShafferDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0003-0150-4043
Allan B MassieDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-5288-5125
Andrew CameronDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Niraj DesaiDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Mark SulkowskiDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jacqueline Garonzik-WangDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Dorry L SegevDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-1924-4801

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2M
Patient Oriented Research in Hepatitis C-infected Injection Drug UsersK24DA034621 · NIDA · JOHNS HOPKINS UNIVERSITY · PI SULKOWSKI, MARK SEBASTIAN · 2012 to 2022
$1.2M
Patient Oriented Research in Solid Organ TransplantationK24AI144954 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGEV, DORRY L. · 2020 to 2024
$956k
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Determinants of chronic kidney disease in African-American live kidney donorsK01DK101677 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MASSIE, ALLAN B · 2015 to 2019
$789k
Aggressive Center Report Cards to Safely Increase Transplantation of Suboptimal KidneysK23DK115908 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI GARONZIK WANG, JACQUELINE M · 2018 to 2021
$516k
Understanding the Impact of HIV on Survival in End-Stage Liver DiseaseF30DK116658 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SHAFFER, ASHTON A · 2017 to 2019
$149k
NIAID NIH HHS K24 AI144954NIDA NIH HHS K24 DA034621NIDDK NIH HHS F30 DK116658NIDDK NIH HHS K01 DK101677NIDDK NIH HHS K23 DK115908NIDDK NIH HHS K24 DK101828NIGMS NIH HHS T32 GM007309
6 · The paper itself

Abstract

Several single-center reports of using HCV-viremic organs for HCV-uninfected (HCV-) recipients were recently published. We sought to characterize national utilization of HCV-exposed donors for HCV- recipients (HCV D+/R-) in kidney transplantation (KT) and liver transplantation (LT). Using SRTR data (April 1, 2015-December 2, 2018) and Gini coefficients, we studied center-level clustering of 1193 HCV D+/R- KTs and LTs. HCV-viremic (NAT+) D+/R- KTs increased from 1/month in 2015 to 22/month in 2018 (LTs: 0/month to 12/month). HCV-aviremic (Ab+/NAT-) D+/R- KTs increased from < 1/month in 2015 to 26/month in 2018 (LTs: <1/month to 8/month). HCV- recipients of viremic and aviremic kidneys spent a median (interquartile range [IQR]) of 0.7 (0.2-1.6) and 1.6 (0.4-3.5) years on the waitlist versus 1.8 (0.5-4.0) among HCV D-/R-. HCV- recipients of viremic and aviremic livers had median (IQR) MELD scores of 24 (21-30) and 25 (21-32) at transplantation versus 29 (23-36) among HCV D-/R-. 12 KT and 14 LT centers performed 81% and 76% of all viremic HCV D+/R- transplants; 11 KT and 13 LT centers performed 76% and 69% of all aviremic HCV D+/R- transplants. There have been marked increases in HCV D+/R- transplantation, although few centers are driving this practice; centers should continue to weigh the risks and benefits of HCV D+/R- transplantation.

Indexed as

AdultAntiviral AgentsFemaleFollow-Up StudiesHepacivirusHepatitis CHumansKidney TransplantationLiver TransplantationMaleMiddle AgedPractice Patterns, Physicians'PrognosisTissue and Organ ProcurementTissue DonorsTransplant RecipientsAntiviral Agentsclinical research/practicehepatitis Cinfection and infectious agents - viralinfectious diseasekidney transplantation/nephrologyliver transplantation/hepatologyOrgan Procurement and Transplantation Network (OPTN)Scientific Registry for Transplant Recipients (SRTR)

Identifiers

PMID30861279
PMCPMC6658335

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.