Evidence map›Paper›PMID 30861153›Full record

ArticleAlcoholism, clinical and experimental research2019

GABA

Lais F Berro, Daniela Rüedi-Bettschen, Jemma E Cook, Lalit K Golani, Guanguan Li, Rajwana Jahan, Farjana Rashid, James M Cook, James K Rowlett, Donna M Platt

Open access · greenAbstract read
In one paragraph

Article in Alcoholism, clinical and experimental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. GABAergic compounds for the treatment of alcohol use disorder.International review of neurobiology · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Melanoma Cell Intrinsic GABAInternational journal of radiation oncology, biology, physics · 2021
    Article
  9. Article
  10. Discriminative Stimulus Effects and Metabolism of Ethanol in Rhesus Monkeys.Alcoholism, clinical and experimental research · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Lais F BerroDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi.
Daniela Rüedi-BettschenDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi.
Jemma E CookDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0002-1698-285X
Lalit K GolaniDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
Guanguan LiDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
Rajwana JahanDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
Farjana RashidDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
James M CookDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
James K RowlettDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi.
Donna M PlattDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi.ORCID 0000-0002-8369-9544
University of Mississippi Medical Center · USUniversity of Wisconsin–Milwaukee · USTulane University · US

Funding

ANXIOLYTIC EFFECTS AND ABUSE OF BZ RECEPTOR LIGANDSR01DA011792 · NIDA · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROWLETT, JAMES K · 1998 to 2024
$7.8M
SELECTIVE ANXIOLYTICS VIA BZR SUBTYPE SPECIFIC LIGANDSR01MH046851 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 1991 to 2010
$4.4M
Tolerance and Physical Dependence after Chronic Benzodiazepine TreatmentR01DA043204 · NIDA · UNIVERSITY OF MISSISSIPPI MED CTR · PI JAMES K ROWLETT · 2017 to 2026
$4.3M
GABAa receptor subtype mechanisms in nonhuman primatesR01AA016179 · NIAAA · UNIVERSITY OF MISSISSIPPI MED CTR · PI PLATT, DONNA M · 2006 to 2016
$3.2M
Neurosteroid-BZ combinations: Strategy for reducing abuse and sedationR01DA033795 · NIDA · UNIVERSITY OF MISSISSIPPI MED CTR · PI ROWLETT, JAMES K · 2012 to 2016
$2.4M
Development of new drugs for asthma by targeting GABA(A) receptors in the lungR01HL118561 · NHLBI · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2014 to 2017
$2.0M
Design of New Therapeutic Agents to Treat SchizophreniaR01MH096463 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2013 to 2017
$1.9M
Synthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic PainR01NS076517 · NINDS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2012 to 2015
$1.3M
NHLBI NIH HHS R01 HL118561NIAAA NIH HHS R01 AA016179NIDA NIH HHS R01 DA011792NIDA NIH HHS R01 DA033795NIDA NIH HHS R01 DA043204NIMH NIH HHS R01 MH046851NIMH NIH HHS R01 MH096463NINDS NIH HHS R01 NS076517
6 · The paper itself

Abstract

backgroundPrevious studies have investigated α1GABA

methodsIn discrimination studies, subjects were trained to discriminate EtOH (2 g/kg, intragastrically) from water under a fixed-ratio (FR) schedule of food delivery. In oral self-administration studies, subjects were trained to self-administer EtOH (2% w/v) or sucrose (0.3 to 1% w/v) under an FR schedule of solution availability.

resultsIn discrimination studies, functionally selective PAMs at α2GABA

conclusionsOur results confirm prior findings regarding the respective roles of α1GABA

Indexed as

AlcoholismAllosteric RegulationAnimalsDiscrimination LearningDose-Response Relationship, DrugEthanolGABA-A Receptor AgonistsGABA-A Receptor AntagonistsMacaca mulattaMaleProtein SubunitsReceptors, GABA-ASelf AdministrationEthanolGABA-A Receptor AgonistsGABA-A Receptor AntagonistsGABRA1 protein, humanGABRA2 protein, humanGABRA3 protein, humanProtein SubunitsReceptors, GABA-AAlphaDrug DiscriminationEthanolGABAASelf-Administration

Identifiers

PMID30861153
PMCPMC6601614
OpenAlexW2921128205

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.