ArticlePsychophysiology2020
Transdiagnostic trauma severity in anxiety and mood disorders: Functional brain activity during emotional scene processing.
Article in Psychophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 45 citations in OpenAlex.
- Aversive perception in a threat context: Separate and independent neural activation.Biological psychology · 2020Trial
- What a stimulus predicts, not what it depicts, determines striatal reward signals.bioRxiv : the preprint server for biology · 2026Article
- Transdiagnostic neural correlates of post-traumatic stress disorder and mild traumatic brain injury.Brain communications · 2026Article
- Precision psychiatry roadmap: towards a biology-informed framework for mental disorders.Molecular psychiatry · 2025Review
- Amygdala Structure and Function: Association With Transdiagnostic Trauma Severity in Anxiety and Mood Disorder Patients.Psychophysiology · 2025Article
- Affective Visual Circuit Dysfunction in Trauma and Stress-Related Disorders.Biological psychiatry · 2025Review
- Neural circuit basis of pathological anxiety.Nature reviews. Neuroscience · 2025Review
- Sex differences in the effects of individual anxiety state on regional responses to negative emotional scenes.Biology of sex differences · 2024Article
- Sensory alterations in post-traumatic stress disorder.Current opinion in neurobiology · 2024Review
- Moving beyond descriptive nosology: an argument for negative valence systems disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Prior Sexual Trauma Exposure Impacts Posttraumatic Dysfunction and Neural Circuitry Following a Recent Traumatic Event in the AURORA Study.Biological psychiatry global open science · 2023Article
- Heightened adolescent emotional reactivity in the brain is associated with lower future distress tolerance and higher depressive symptoms.Psychiatry research. Neuroimaging · 2023Article
- A Neurobiological Profile Underlying Comorbidity Load and Prospective Increases in Dysphoria in a Focal Fear Sample.Biological psychiatry · 2023Article
- Mood and anxiety disorders within the Research Domain Criteria framework of Positive and Negative Valence Systems: a scoping review.Frontiers in human neuroscience · 2023Article
- Revisiting the seven pillars of RDoC.BMC medicine · 2022Article
- Vulnerable Dispositional Traits and Chronic Pain: Predisposing but not Predetermining.The journal of pain · 2022Article
- Developmental trauma: Conceptual framework, associated risks and comorbidities, and evaluation and treatment.Frontiers in psychiatry · 2022Review
- Childhood Maltreatment Influences Autonomic Regulation and Mental Health in College Students.Frontiers in psychiatry · 2022Article
- Morally Distressing Experiences, Moral Injury, and Burnout in Florida Healthcare Providers during the COVID-19 Pandemic.International journal of environmental research and public health · 2021Article
- What's in a Face? Amygdalar Sensitivity to an Emotional Threatening Faces Task and Transdiagnostic Internalizing Disorder Symptoms in Participants Receiving Attention Bias Modification Training.Cognitive therapy and research · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Exposure to traumatic events is not unique to post-traumatic stress disorder (PTSD) and is a significant factor in the development of physical and mental disease across the diagnostic spectrum. Using fMRI, this study assesses functional activation in the amygdala and visual cortex during emotional scene processing in a sample of anxiety and mood disorder patients (N = 162). Replicating previous studies with healthy young participants, a strong covariation was found between functional activity in the amygdala and ventral visual cortex, with blood-oxygen-level dependent (BOLD) activity overall significantly enhanced in both regions when viewing emotionally arousing, compared to neutral, scenes. BOLD changes during emotional processing predicted questionnaire reports of experienced trauma and PTSD-like symptoms (e.g., intrusive thoughts, bad dreams, re-experiencing) and associated functional impairment. Patients showing the smallest BOLD changes when viewing emotional (compared to neutral) scenes in the amygdala and ventral visual cortex reported the highest trauma scores, whereas those patients with the largest amygdala emotional reactivity differences reported the lowest trauma scores. Experiencing a life-threatening event (to self or other) that prompts high fear, distress, and functional impairment was associated with reduced functional limbic-visual activity, independent of a PTSD diagnosis. The findings suggest that experienced trauma may be a transdiagnostic vulnerability factor contributing significantly to psychopathology in many patients with anxiety and mood disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.