ArticleThe Journal of comparative neurology2019
New viral-genetic mapping uncovers an enrichment of corticotropin-releasing hormone-expressing neuronal inputs to the nucleus accumbens from stress-related brain regions.
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Article in The Journal of comparative neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
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Who cites it
44 citing papers in PubMed, 63 citations in OpenAlex.
- Early adversity promotes adolescent avoidance behavior by enhancing prefrontal-amygdala communication through CRHbioRxiv : the preprint server for biology · 2026Article
- Early-life stress impairs development of functional interactions and neuronal activity within prefrontal-amygdala networks in vivo.Molecular psychiatry · 2026Article
- Corticotropin releasing hormone-expressing inputs to the thalamic paraventricular nucleus: pathways from mother to memory?Neurobiology of stress · 2026Article
- Sex and Stress Govern the Function and Innervation of a Basolateral Amygdala to Nucleus Accumbens Corticotropin-Releasing Hormone/GABA-Expressing Projection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Control of feeding behavior by modified retrograde AAV to the gastrointestinal tract nerve afferents.Scientific reports · 2025Article
- Brain-Wide Patterns of CRF Receptor 1 Expression in the Transgenic CRFR1-Cre-2a-tdTom Rat.The Journal of comparative neurology · 2025Article
- The evolving neurobiology of early-life stress.Neuron · 2025Review
- Extended amygdala corticotropin-releasing hormone neurons regulate sexually dimorphic changes in pair bond formation following social defeat in prairie voles (Microtus ochrogaster).Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Corticotropin-Releasing Factor Release From a Unique Subpopulation of Accumbal Neurons Constrains Action-Outcome Acquisition in Reward Learning.Biological psychiatry · 2025Article
- Targeting corticotropin-releasing hormone receptor type 1 (Crhr1) neurons: validating the specificity of a novel transgenic Crhr1-FlpO mouse.Brain structure & function · 2024Article
- Extended amygdala corticotropin-releasing hormone neurons regulate sexually dimorphic changes in pair bond formation following social defeat in prairie voles (bioRxiv : the preprint server for biology · 2024Article
- Nucleus Accumbens Corticotropin-Releasing Hormone Neurons Projecting to the Bed Nucleus of the Stria Terminalis Promote Wakefulness and Positive Affective State.Neuroscience bulletin · 2024Article
- Corticotropin releasing factor alters the functional diversity of accumbal cholinergic interneurons.Journal of neurophysiology · 2024Article
- CRF regulates pain sensation by enhancement of corticoaccumbal excitatory synaptic transmission.Molecular psychiatry · 2024Article
- Chronic Nicotine Consumption and Withdrawal Regulate Melanocortin Receptor, CRF, and CRF Receptor mRNA Levels in the Rat Brain.Brain sciences · 2024Article
- Genetic Tagging Uncovers a Robust, Selective Activation of the Thalamic Paraventricular Nucleus by Adverse Experiences Early in Life.Biological psychiatry global open science · 2023Article
- Opto-juxtacellular interrogation of neural circuits in freely moving mice.Nature protocols · 2023Review
- Cocaine Regulates NLRP3 Inflammasome Activity and CRF Signaling in a Region- and Sex-Dependent Manner in Rat Brain.Biomedicines · 2023Article
- Sex-related differences in endogenous pituitary adenylate cyclase-activating polypeptide (PACAP) in the thalamic paraventricular nucleus: Implications for addiction neuroscience.Addiction neuroscience · 2023Article
- Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice.Nature communications · 2023Article
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Authors and funding
10 authors at 1 institution in 1 country.
Christy A ItogaDepartment of Anatomy and Neurobiology, School of Medicine, University of California-Irvine, Irvine, California.ORCID 0000-0002-6740-5577
Yuncai ChenDepartment of Anatomy and Neurobiology, School of Medicine, University of California-Irvine, Irvine, California.
Cameron FateriDepartment of Anatomy and Neurobiology, School of Medicine, University of California-Irvine, Irvine, California.
Paula A EcheverryDepartment of Anatomy and Neurobiology, School of Medicine, University of California-Irvine, Irvine, California.
Jennifer M LaiDepartment of Anatomy and Neurobiology, School of Medicine, University of California-Irvine, Irvine, California.
Jasmine DelgadoDepartment of Anatomy and Neurobiology, School of Medicine, University of California-Irvine, Irvine, California.
Shapatur BadhonDepartment of Anatomy and Neurobiology, School of Medicine, University of California-Irvine, Irvine, California.
Annabel ShortDepartment of Anatomy and Neurobiology, School of Medicine, University of California-Irvine, Irvine, California.
Tallie Z BaramDepartment of Anatomy and Neurobiology, School of Medicine, University of California-Irvine, Irvine, California.ORCID 0000-0003-0771-8616
Xiangmin XuDepartment of Anatomy and Neurobiology, School of Medicine, University of California-Irvine, Irvine, California.ORCID 0000-0002-5828-1533
University of California, Irvine · US
Funding
Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9MStructural & Network-Function Correlates of Fragmented Early-Life Across SpeciesP50MH096889 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z. · 2013 to 2023
$25.4MEpilepsy Research Training ProgramT32NS045540 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Tallie Z. Baram, Robert F Hunt · 2003 to 2026
$4.9MEffects of Early-Life Experience: Role of CRHR01MH073136 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z. · 2005 to 2020
$4.6MInhibitory neuron circuit organization and function in prefrontal cortex.R01MH105427 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLSHANI, PEYMAN, XU, XIANGMIN · 2015 to 2019
$2.3MNeural circuit organization and function of the bed nucleus of the stria terminalisR01MH113026 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI XU, XIANGMIN · 2017 to 2021
$2.2MHippocampal inhibitory neuronal circuit organizationR01NS078434 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI XU, XIANGMIN · 2012 to 2016
$1.6MHigh-resulution and cell-type-specific mapping of synaptic circuit organization in the bed nucleus of the stria terminalisR21MH112085 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI XU, XIANGMIN · 2017 to 2018
$425kNCI NIH HHS P30 CA062203NIMH NIH HHS P50 MH096889NIMH NIH HHS R01 MH073136NIMH NIH HHS R01 MH105427NIMH NIH HHS R01 MH113026NIMH NIH HHS R21 MH112085NINDS NIH HHS R01 NS078434NINDS NIH HHS T32 NS045540
Abstract
Corticotropin-releasing hormone (CRH) is an essential, evolutionarily-conserved stress neuropeptide. In addition to hypothalamus, CRH is expressed in brain regions including amygdala and hippocampus where it plays crucial roles in modulating the function of circuits underlying emotion and cognition. CRH
Indexed as
AnimalsCorticotropin-Releasing HormoneDependovirusFemaleGenes, ReporterGenetic TechniquesGenetic VectorsMaleMiceMice, Inbred C57BLNeural PathwaysNucleus AccumbensPsychological DistressCorticotropin-Releasing Hormonecircuitrycorticotropin-releasing factorCRHmolecular-specific pathwaysnucleus accumbensrewardRRID: AB_2313584RRID: AB_2716806RRID: IMSR_JAX:012704stresstransgenic miceviral tracing
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.