Evidence map›Paper›PMID 30861114›Full record

ArticleInternational journal of cancer2020

Absolute risks of cervical precancer among women who fulfill exiting guidelines based on HPV and cytology cotesting.

Rebecca Landy, Mark Schiffman, Peter D Sasieni, Li C Cheung, Hormuzd A Katki, Greg Rydzak, Nicolas Wentzensen, Nancy E Poitras, Thomas Lorey, Walter K Kinney and 1 more

Abstract read
In one paragraph

Article in International journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. The Improving Risk Informed HPV Screening (IRIS) Study: Design and Baseline Characteristics.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rebecca LandyCentre for Cancer Prevention, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, United Kingdom.ORCID 0000-0003-4042-4820
Mark SchiffmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA.
Peter D SasieniFaculty of Life Sciences & Medicine, School of Cancer & Pharmaceutical Sciences, Guys Cancer Centre, Guys Hospital, King's College London, London, SE1 9RT, United Kingdom.
Li C CheungDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA.
Hormuzd A KatkiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA.
Greg RydzakInformation Management Services Inc., Calverton, MD, USA.
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, USA.
Nancy E PoitrasRegional Laboratory, Kaiser Permanente Northern California, Berkeley, CA, USA.
Thomas LoreyRegional Laboratory, Kaiser Permanente Northern California, Berkeley, CA, USA.
Walter K KinneyDivision of Gynaecologic Oncology, Kaiser Permanente Medical Care Program, Oakland, CA, USA.
Philip E CastleAlbert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0003-1082-6554

Funding

Cervical Cancer MoonshotZIACP010230 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SCHIFFMAN, MARK · 2018 to 2025
$33.8M
Human papillomavirus (HPV) infection and cervical and anal cancersZIACP010124 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI WENTZENSEN, NICOLAS · 2009 to 2025
$17.3M
Cancer Research UK 16892Cancer Research UK 20303Cancer Research UK 27047Cancer Research UK A16892Cancer Research UK A20303Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA CP010124Intramural NIH HHS ZIA CP010230
6 · The paper itself

Abstract

US guidelines recommend that most women older than 65 years cease cervical screening after two consecutive negative cotests (concurrent HPV and cytology tests) in the previous 10 years, with one in the last 5 years. However, this recommendation was based on expert opinion and modeling rather than empirical data on cancer risk. We therefore estimated the 5-year risks of cervical precancer (cervical intraepithelial neoplasia grade 3 or adenocarcinoma in situ [CIN3]) after one, two and three negative cotests among 346,760 women aged 55-64 years undergoing routine cotesting at Kaiser Permanente Northern California (2003-2015). Women with a history of excisional treatment or CIN2+ were excluded. No woman with one or more negative cotests was diagnosed with cancer during follow-up. Five-year risks of CIN3 after one, two, and three consecutive negative cotests were 0.034% (95% CI: 0.023%-0.046%), 0.041% (95% CI: 0.007%-0.076%) and 0.016% (95% CI: 0.000%-0.052%), respectively (p

Indexed as

Adenocarcinoma in SituCaliforniaCervix UteriEarly Detection of CancerFemaleHumansMass ScreeningMiddle AgedPapillomaviridaePapillomavirus InfectionsPractice Guidelines as TopicPrecancerous ConditionsProspective StudiesRisk AssessmentUterine Cervical DysplasiaUterine Cervical Neoplasmscervical cancercervical screeningcotestingexitingguidelinesHPV

Identifiers

PMID30861114
PMCPMC6742586

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.