Evidence map›Paper›PMID 30861060›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2019

Loa loa Microfilariae in Skin Snips: Consequences for Onchocerciasis Monitoring and Evaluation in L. loa-Endemic Areas.

Hugues C Nana-Djeunga, Floribert Fossuo-Thotchum, Sébastien D Pion, Cédric B Chesnais, Joseph Kubofcik, Charles D Mackenzie, Amy D Klion, Michel Boussinesq, Thomas B Nutman, Joseph Kamgno

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Filarial disease in the Brazilian Amazon and emerging opportunities for treatment and control.Current research in parasitology & vector-borne diseases · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Frontiers in tropical diseases · 2021
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Hugues C Nana-DjeungaCentre for Research on Filariasis and Other Tropical Diseases, Yaounde, Cameroon.
Floribert Fossuo-ThotchumCentre for Research on Filariasis and Other Tropical Diseases, Yaounde, Cameroon.
Sébastien D PionInstitut de Recherche pour le Développement (IRD), Unité Mixte Internationale (UMI) 233-Institut National de la Santé et de la Recherche Médicale (INSERM) U1175, Montpellier University, France.
Cédric B ChesnaisInstitut de Recherche pour le Développement (IRD), Unité Mixte Internationale (UMI) 233-Institut National de la Santé et de la Recherche Médicale (INSERM) U1175, Montpellier University, France.
Joseph KubofcikLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.
Charles D MackenzieNeglected Tropical Diseases Support Center, Task Force for Global Health, Atlanta, Georgia.
Amy D KlionLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.
Michel BoussinesqInstitut de Recherche pour le Développement (IRD), Unité Mixte Internationale (UMI) 233-Institut National de la Santé et de la Recherche Médicale (INSERM) U1175, Montpellier University, France.
Thomas B NutmanLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland.
Joseph KamgnoCentre for Research on Filariasis and Other Tropical Diseases, Yaounde, Cameroon.
Inserm · FRNational Institute of Allergy and Infectious Diseases · USThe Task Force for Global Health · USUniversité de Yaoundé I · CM

Funding

Molecular Definition Of Filarial And Related Nonfilarial Genes And ProteinsZIAAI000512 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NUTMAN, THOMAS · 2009 to 2025
$9.9M
6 · The paper itself

Abstract

The specificity of skin snips for onchocerciasis diagnoses is considered to be almost 100%. Our molecular methods revealed that microfilariae emerging from skin snips collected from highly microfilaremic Loa loa-infected individuals were largely misidentified as Onchocerca volvulus. This has important implications for onchocerciasis diagnostic testing in Loa-endemic areas.

Indexed as

AdolescentAdultAgedAged, 80 and overAnimalsChildFemaleHumansLoaLoiasisMaleMicrofilariaeMiddle AgedOnchocerca volvulusOnchocerciasisYoung AdultdiagnosisfilariasisLoa loaOnchocerca volvulusskin snip

Identifiers

PMID30861060
PMCPMC6792118
OpenAlexW2921020279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.