ArticlePloS one2019
The role of surgery and radiation in advanced gastric cancer: A population-based study of Surveillance, Epidemiology, and End Results database.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Circulating tumor DNA and prognosis in gastric cancer patients undergoing surgery: meta-analysis and trial sequential analysis.Frontiers in oncology · 2026Pooled it
- Antitumor Effects of Resveratrol Opposing Mechanisms ofNutrients · 2024Review
- EZH2: An Accomplice of Gastric Cancer.Cancers · 2023Review
- Development and validation of nomogram models to predict radiotherapy or chemotherapy benefit in stage III/IV gastric adenocarcinoma with surgery.Frontiers in oncology · 2023Article
- Developing and validating nomograms for predicting the survival in patients with clinical local-advanced gastric cancer.Frontiers in oncology · 2022Article
- The Influence of Heavy Metals on Gastric Tumorigenesis.Journal of oncology · 2022Article
- Long-term survival after multidisciplinary treatments for advanced esophagogastric junction cancer.International cancer conference journal · 2021Article
- Diagnostic and prognostic values of anti-helicobacter pylori antibody combined with serum CA724, CA19-9, and CEA for young patients with early gastric cancer.Journal of clinical laboratory analysis · 2020Article
- The Preoperative Enhanced Degree of Contrast-enhanced CT Images: A Potential Independent Predictor in Gastric Adenocarcinoma Patients After Radical Gastrectomy.Cancer management and research · 2020Article
- Multi-Modality Treatment for Patients With Metastatic Gastric Cancer: A Real-World Study in China.Frontiers in oncology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChemotherapy is the standard approach for advanced gastric cancer, while the role of local therapy such as surgery and radiation for this population remains controversial. Our purpose is to evaluate the effect of local therapies on cancer specific survival (CSS) for advanced gastric cancer patients.
methodsFour subgroups of patients in different treatment strategies: surgery, radiation (RT), surgery and radiation (Surgery+RT), no surgery/no radiation (No Surgery/No RT) were identified from the Surveillance, Epidemiology, and End Results (SEER)-registered database. The risk factors and the survival outcomes were analyzed by multivariable Cox regression models and Kaplan-Meier methods.
resultsA total of 10,354 patients were eligible with 6658 males and 3696 females. The 5-year CSS in the four subgroups of "Surgery", "RT", "Surgery+RT" and "No Surgery/No RT" were respectively 8.9%. 5.7%, 19.8% and 3.2%, which were significantly different in multivariate Cox regression (P<0.001) and univariate log-rank test (P<0.001). Advanced stage categories were defined as stage I, II and III of T/N category according to different initial T and N status following American Joint Committee on Cancer (AJCC) staging principle. Further analysis showed that patients in the group of "Surgery+RT" have significant benefits of survival specifically on stage II and III of T/N category. "Surgery+RT" group and "Surgery" group patients have similar survival time in stage I of T/N category. Moreover, we also found CSS benefits from the administration of "Surgery+RT" in the patients aged both ≥75 and <75 years. Remarkably, patients in "Surgery" group have no different survival time with "RT" group in age category of 75 years and older.
conclusionsLocal therapies, including surgery, radiation, and combination of both might associate to improve survival in advanced gastric cancer patients, but confounding due to disease extent and physical status cannot be excluded.
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