ArticlePloS one2019
Application of a self-assembling peptide matrix prevents esophageal stricture after circumferential endoscopic submucosal dissection in a pig model.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06698419 (A Prospective Study), which is not on this map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Study: The Effect of RADA16 on Mastoid Cavity Epithelialization After Canal Wall Down Mastoidectomy
Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- A novel approach to preventing adverse events after circumferential endoscopic submucosal dissection of the ileocecal valve.Endoscopy · 2026Article
- Self-assembling peptide hydrogel prevents esophageal stenosis after endoscopic submucosal dissection for esophageal squamous cell carcinoma: Multicenter prospective study.Endoscopy international open · 2026Article
- Endoscopic Image-Based Prediction of Esophageal Stenosis after ESD Using Mucosal Defect Metrics.Annals of surgical oncology · 2025Article
- A novel self-assembling peptide as new submucosal injection solution in endoscopic submucosal dissection.Surgical endoscopy · 2025Article
- Endoscopic incisional therapy for an epithelialized coin in the proximal esophagus and self-assembling peptide hydrogel use in a toddler.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2025Article
- Hydrogels for preventing post-endoscopic submucosal dissection stenosis in early esophageal cancer: a comprehensive literature review.Therapeutic advances in gastroenterology · 2025Review
- Use of a self-assembling peptide to control complications associated with endoscopic balloon dilation of refractory anastomotic stricture.Endoscopy · 2024Article
- Application of the Self-Assembling Peptide Hydrogel RADA16 for Hemostasis during Tonsillectomy: A Feasibility Study.Journal of functional biomaterials · 2024Article
- Release systems based on self-assembling RADA16-I hydrogels with a signal sequence which improves wound healing processes.Scientific reports · 2023Article
- The Use of Peptides in Veterinary Serodiagnosis of Infectious Diseases: A Review.Veterinary sciences · 2022Review
- Prevention of Esophageal Stricture After Whole Circumferential Endoscopic Resection: A Review for Endoscopists.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022Review
- Comparison of PuraStat self-assembling peptide hydrogel versus mineral-based Hemospray for endoscopic hemostasis of upper and lower gastrointestinal lesions in pigs.Frontiers in gastroenterology (Lausanne, Switzerland) · 2022Article
- Novel Hemostatic Gel As Rescue Therapy for Postsphincterotomy Bleeding Refractory to Self-Expanding Metallic Stent Placement.ACG case reports journal · 2022Article
- Clinical Use of the Self-Assembling Peptide RADA16: A Review of Current and Future Trends in Biomedicine.Frontiers in bioengineering and biotechnology · 2021Review
- PuraStat RADA16 Self-Assembling Peptide Reduces Postoperative Abdominal Adhesion Formation in a Rabbit Cecal Sidewall Injury Model.Frontiers in bioengineering and biotechnology · 2021Article
- Prevention of Stricture after Endoscopic Submucosal Dissection for Superficial Esophageal Cancer: A Review of the Literature.Journal of clinical medicine · 2020Review
- Review
- Use of Purastat, a novel haemostatic matrix based on self-assembling peptides in the prevention of nasopharyngeal adhesion formation.International journal of surgery case reports · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCircumferential endoscopic submucosal dissection (ESD) allows to treat large esophageal superficial neoplasms, however with a high occurrence of severe esophageal strictures. In a previous work, we demonstrated that the application of a prototype of self-assembling peptide (SAP) matrix on esophageal wounds after a circumferential-ESD delayed the onset of esophageal stricture in a porcine model. The aim of this work was to consolidate these results using the commercialized version of this SAP matrix currently used as a hemostatic agent. ANIMALS AND
methodsEleven pigs underwent a 5 cm-long circumferential esophageal ESD under general anesthesia. Five pigs were used as a control group and six were treated with the SAP. In the experimental group, 3.5 mL of the SAP matrix were immediately applied on the ESD wound. Stricture rates and esophageal diameter were assessed at day 14 by endoscopy and esophagram, followed by necropsy and histological measurements of inflammation and fibrosis in the esophageal wall.
resultsAt day 14, two animals in the treated group had an esophageal stricture without any symptom, while all animals in the control group had regurgitations and an esophageal stricture (33 vs. 100%, p = 0.045). In the treated group, the mean esophageal diameter at day 14 was 9.5 ± 1 mm vs. 4 ± 0.6 mm in the control group (p = 0.004). Histologically, the neoepithelium was longer in the SAP treated group vs. the control (3075 μm vs. 1155μm, p = 0.014). On immunohistochemistry, the expression of alpha smooth muscle actin was lower in the treated vs. control group.
conclusionApposition of a self-assembling peptide matrix immediately after a circumferential esophageal ESD reduced by 67% the occurrence of a stricture at day 14, by promoting reepithelialization of the resected area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.