ArticleAmerican journal of physiology. Endocrinology and metabolism2019
Transgenerational impact of maternal obesogenic diet on offspring bile acid homeostasis and nonalcoholic fatty liver disease.
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Article in American journal of physiology. Endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Maternal obesogenic diet exposure regulates the offspring gut liver axis and fibroinflammatory liver disease.Communications biology · 2025Article
- Mitochondrial dysfunction characterises the multigenerational effects of maternal obesity on MASLD.JHEP reports : innovation in hepatology · 2025Article
- Maternal Western Diet Programmes Bile Acid Dysregulation and Hepatic Fibrosis in Fetal and Juvenile Macaques.Liver international : official journal of the International Association for the Study of the Liver · 2025Article
- Maternal high-fat high-sugar diet impairs bone quality and strength but not cartilage in aging mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Review
- Nutritional Approaches Targeting Gut Microbiota in Oxidative-Stress-Associated Metabolic Syndrome: Focus on Early Life Programming.Nutrients · 2024Review
- Maternal Obesogenic Diet Attenuates Microbiome-Dependent Offspring Weaning Reaction with Worsening of Steatotic Liver Disease.The American journal of pathology · 2024Article
- Janus kinase-signal transducer and activator of transcription signaling pathway in the ocular cells of rat fetuses exposed to maternal saturated fat ingestion.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Genetic Ablation of C/EBPα-p300 Pathway Blocks Development of Obese Pregnancy Associated Liver Disorders in Offspring.Cellular and molecular gastroenterology and hepatology · 2024Article
- Thermoneutral Housing Enables Studies of Vertical Transmission of Obesogenic Diet-Driven Metabolic Diseases.Nutrients · 2023Article
- Maternal Exercise Protects Male Offspring From Maternal Diet-Programmed Nonalcoholic Fatty Liver Disease Progression.Endocrinology · 2023Article
- Impaired Carbohydrate Metabolism and Excess of Lipid Accumulation in Offspring of Hyperandrogenic Mice.Metabolites · 2022Article
- Maternal obesogenic diet enhances cholestatic liver disease in offspring.Journal of lipid research · 2022Article
- Maternal obesogenic diet regulates offspring bile acid homeostasis and hepatic lipid metabolism via the gut microbiome in mice.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- MCP-1 Signaling Disrupts Social Behavior by Modulating Brain Volumetric Changes and Microglia Morphology.Molecular neurobiology · 2022Article
- Western diet-induced shifts in the maternal microbiome are associated with altered microRNA expression in baboon placenta and fetal liver.Frontiers in clinical diabetes and healthcare · 2022Article
- Developmental origins of metabolic diseases.Physiological reviews · 2021Review
- Developmental Programming of NAFLD by Parental Obesity.Hepatology communications · 2020Review
- Nutrition Transition and Cancer.Nutrients · 2020Review
- Maternal Genistein Intake Mitigates the Deleterious Effects of High-Fat Diet on Glucose and Lipid Metabolism and Modulates Gut Microbiota in Adult Life of Male Mice.Frontiers in physiology · 2019Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Michael D ThompsonDivision of Endocrinology and Diabetes, Department of Pediatrics, Washington University in St. Louis, St. Louis, Missouri.
Alaina DerseDivision of Endocrinology and Diabetes, Department of Pediatrics, Washington University in St. Louis, St. Louis, Missouri.
Jeremie LA FereyDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, St. Louis, Missouri.
Michaela ReidDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, St. Louis, Missouri.
Yan XieDivision of Gastroenterology, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.
Miranda ChristDivision of Endocrinology and Diabetes, Department of Pediatrics, Washington University in St. Louis, St. Louis, Missouri.
Deyali ChatterjeeDeparment of Pathology, Washington University in St. Louis, St. Louis, Missouri.
Chau NguyenDivision of Endocrinology and Diabetes, Department of Pediatrics, Washington University in St. Louis, St. Louis, Missouri.
Natalia HarasymowiczDepartment of Orthopedic Surgery, Washington University in St. Louis, St. Louis, Missouri.
Farshid GuilakDepartment of Orthopedic Surgery, Washington University in St. Louis, St. Louis, Missouri.
Kelle H MoleyDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, St. Louis, Missouri.
Nicholas Oliver DavidsonDivision of Gastroenterology, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.
Washington University in St. Louis · US
Funding
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWashington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI James Alexander Fitzpatrick · 2013 to 2026
$27.1MChild Health Research CenterK12HD076224 · NICHD · WASHINGTON UNIVERSITY · PI MARK E. LOWE · 2013 to 2026
$6.2MHEPATIC SYNTHESIS AND SECRETION OF APOLIPOPROTEIN (A)R01DK056260 · NIDDK · WASHINGTON UNIVERSITY · PI DAVIDSON, NICHOLAS O. · 1999 to 2017
$5.9MENTEROHEPATIC LIPID FLUX AND APOPROTEIN BIOSYNTHESIS.R37HL038180 · NHLBI · WASHINGTON UNIVERSITY · PI DAVIDSON, NICHOLAS O. · 2000 to 2009
$5.1MENTEROHEPATIC LIPID FLUX AND APOPROTEIN BIOSYNTHESISR01HL038180 · NHLBI · WASHINGTON UNIVERSITY · PI DAVIDSON, NICHOLAS O. · 1986 to 2018
$3.8MImpaired VLDL secretion, progression and reversal of hepatic fibrogenesisR01DK119437 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2019 to 2026
$3.8MMaternal nutrition and oocyte programmingR01HD083895 · NICHD · WASHINGTON UNIVERSITY · PI ENGLAND, SARAH K. · 2015 to 2019
$2.7MCardiac and mitochondrial deficiencies across three generations arising from maternal obesityF32HL140848 · NHLBI · WASHINGTON UNIVERSITY · PI FEREY, JEREMIE LUC ALLEN · 2018 to 2019
$120kNCATS NIH HHS UL1 TR002345NHLBI NIH HHS F32 HL140848NHLBI NIH HHS R01 HL038180NHLBI NIH HHS R37 HL038180NICHD NIH HHS K12 HD076224NICHD NIH HHS R01 HD083895NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK052574NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK056260NIDDK NIH HHS R01 DK119437
Abstract
Studies show maternal obesity is a risk factor for metabolic syndrome and nonalcoholic fatty liver disease (NAFLD) in offspring. Here we evaluated potential mechanisms underlying these phenotypes. Female C57Bl6 mice were fed chow or an obesogenic high-fat/high-sucrose (HF/HS) diet with subsequent mating of F
Indexed as
DietAnimalsBile Acids and SaltsCholesterolDietary FatsDietary SucroseDiet, High-FatFemaleFibrosisFructoseHomeostasisInflammationLiverMaleMetabolic SyndromeMiceBile Acids and SaltsCholesterolDietary FatsDietary SucroseFructoseTrans Fatty AcidsTriglyceridesbile acid metabolismfatty liverliver fibrosismaternal high-fat/high-sucrose diet
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.