ArticleOrganic letters2019
A Mild, DNA-Compatible Nitro Reduction Using B
Article in Organic letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 88 citations in OpenAlex.
- Photoinduced reduction of nitro(hetero)arenes with earth-abundant FeClRSC advances · 2026Article
- Pyridine-boryl radical mediated synthesis of quinolinesOrganic chemistry frontiers : an international journal of organic chemistry · 2026Article
- Metal-Free, Chemoselective Reduction of Aromatic Nitro Compounds in Water at Room Temperature.ChemistryOpen · 2026Article
- Discovery of a novel small molecule degrader of wild type and mutant estrogen receptors using DNA encoded libraries.NPJ breast cancer · 2025Article
- Prodrug activation by 4,4'-bipyridine-mediated aromatic nitro reduction.Nature communications · 2024Article
- FSOACS medicinal chemistry letters · 2024Article
- Pd/NHC catalyzed reduction and coupling of nitroaromatics for the synthesis of diarylamines.RSC advances · 2024Article
- Negishi-coupling-enabled synthesis of α-heteroaryl-α-amino acid building blocks for DNA-encoded chemical library applications.Beilstein journal of organic chemistry · 2024Article
- Boron Triiodide-Mediated Reduction of Nitroarenes Using Borohydride Reagents.Organic letters · 2023Article
- One-pot reductive amination of carbonyl compounds and nitro compoundsRSC advances · 2023Article
- Metal-Free and Open-Air Arylation Reactions of Diaryliodonium Salts for DNA-Encoded Library Synthesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Opportunities for Expanding Encoded Chemical Diversification and Improving Hit Enrichment in mRNA-Displayed Peptide Libraries.Chembiochem : a European journal of chemical biology · 2022Review
- Reductive site-selective atypicalScience advances · 2022Article
- Converting Double-Stranded DNA-Encoded Libraries (DELs) to Single-Stranded Libraries for More Versatile Selections.ACS omega · 2022Article
- In-solution direct oxidative coupling for the integration of sulfur/selenium into DNA-encoded chemical libraries.Chemical science · 2022Article
- DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 MProceedings of the National Academy of Sciences of the United States of America · 2021Article
- DNA-Encoded Chemistry: Drug Discovery from a Few Good Reactions.Chemical reviews · 2021Review
- Discovery and characterization of bromodomain 2-specific inhibitors of BRDT.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Review
- Discovery of potent thrombin inhibitors from a protease-focused DNA-encoded chemical library.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
A hypodiboric acid system for the reduction of nitro groups on DNA-chemical conjugates has been developed. This transformation provided good to excellent yields of the reduced amine product for a variety of functionalized aromatic, heterocyclic, and aliphatic nitro compounds. DNA tolerance to reaction conditions, extension to decigram scale reductions, successful use in a DNA-encoded chemical library synthesis, and subsequent target selection are also described.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.