ArticleThe EMBO journal1986
Interleukin-3-dependent expression of the c-myc and c-fos proto-oncogenes in hemopoietic cell lines.
Article in The EMBO journal, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 89 citations in OpenAlex.
- IL-3-Induced Immediate Expression of c-Cells · 2022Article
- Coupling of osteopontin and its cell surface receptor CD44 to the cell survival response elicited by interleukin-3 or granulocyte-macrophage colony-stimulating factor.Molecular and cellular biology · 2000Article
- The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB.Molecular and cellular biology · 1999Article
- STAT3 is required for the gp130-mediated full activation of the c-myc gene.The Journal of experimental medicine · 1999Article
- Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.Molecular and cellular biology · 1995Article
- A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transduction.Molecular and cellular biology · 1994Article
- JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region.Molecular and cellular biology · 1994Article
- Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling.The EMBO journal · 1993Article
- Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors.Molecular and cellular biology · 1993Article
- Article
- Regulation of interleukin 3 mRNA expression in mast cells occurs at the posttranscriptional level and is mediated by calcium ions.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- EGF induces differentiation of an IL-3-dependent cell line expressing the EGF receptor.The EMBO journal · 1989Article
- A v-H-ras-dependent hemopoietic tumor model involving progression from a clonal stage of transformation competence to autocrine interleukin 3 production.Molecular and cellular biology · 1989Article
- Fos C-terminal mutations block down-regulation of c-fos transcription following serum stimulation.The EMBO journal · 1988Article
- Regulation of c-myc and c-fos proto-oncogene expression by animal cell growth factors.In vitro cellular & developmental biology : journal of the Tissue Culture Association · 1988Review
- The calcium signal for BALB/MK keratinocyte terminal differentiation counteracts epidermal growth factor (EGF) very early in the EGF-induced proliferative pathway.Molecular and cellular biology · 1988Article
- Transcription of proto-oncogenes in Rous sarcoma virus infected and transformed chicken embryo cells.Archives of virology · 1988Article
- Nature and specificity of lymphokine independence induced by a selectable retroviral vector expressing v-src.Molecular and cellular biology · 1987Article
- Altered protein kinase C in a mast cell variant defective in exocytosis.Proceedings of the National Academy of Sciences of the United States of America · 1987Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using Northern blot analysis the expression of several proto-oncogenes was studied in established lines of mast cell precursors. Upon removal of interleukin-3 (IL-3) from the culture medium, factor-dependent cells stop dividing. During the first 7 h, however, normal amounts of total cellular mRNAs are maintained, and this is reflected in unchanged levels of several transcripts, such as actin, c-Ha-ras and c-fes. In contrast, within 1.5 h of IL-3 removal, the levels of c-myc and c-fos mRNAs decrease drastically and addition of IL-3 at that stage quickly induces back the levels found in actively growing cultures. In factor-independent cells, which proliferate actively even in the absence of IL-3, high levels of c-myc and c-fos transcripts are maintained in the absence of growth factor. In cells arrested by serum starvation, addition of 10% serum induces massive amounts of c-fos transcripts, but not of c-myc, and cell proliferation is not restored. The data suggest that the c-myc and c-fos proto-oncogenes play an important role in mediating the multiple effects of IL-3 on hemopoietic progenitor cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.