Evidence map›Paper›PMID 30860665›Full record

ArticleJournal of biomedical materials research. Part B, Applied biomaterials2019

Biodegradable hyaluronan hydrogel coatings on acellular dermis grafts-A potential strategy to improve biologic graft durability in hernia repair application.

Sambit Sahoo, Jinjin Ma, Luciano Tastaldi, Andrew R Baker, Jacki Loftis, Michael J Rosen, Kathleen A Derwin

Open access · greenAbstract read
In one paragraph

Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sambit SahooDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Jinjin MaDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Luciano TastaldiDepartment of General Surgery, Cleveland Clinic, Cleveland, Ohio.
Andrew R BakerDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Jacki LoftisDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Michael J RosenDepartment of General Surgery, Cleveland Clinic, Cleveland, Ohio.
Kathleen A DerwinDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Cleveland Clinic Lerner College of Medicine · USCleveland Clinic · US

Funding

Hyaluronan Barrier Coating as a Strategy to Improve Durability of Biologic Hernia GraftsR21EB022668 · NIBIB · CLEVELAND CLINIC LERNER COM-CWRU · PI SAHOO, SAMBIT · 2016 to 2017
$436k
NIBIB NIH HHS 5R21EB022668NIBIB NIH HHS R21 EB022668
6 · The paper itself

Abstract

Biologic grafts used in hernia repair undergo rapid cellular infiltration and remodeling, but their premature degradation often results in hernia recurrence. We hypothesize that a temporary barrier that prevents infiltration of acute inflammatory cells into the graft during the initial 4 weeks of implantation could mitigate graft degradation. The purpose of this study is to design tyramine-substituted hyaluronan (THA) hydrogel coatings with tunable degradation properties, as a means to develop a resorbable barrier for human acellular dermis grafts (HADM). THA plugs prepared at different cross-linking densities, by varying cross-linking agent concentration (0.0001-0.0075% H

Indexed as

Coated Materials, BiocompatibleHerniorrhaphyHyaluronic AcidHydrogelsAnimalsDermisHumansMaleRatsRats, Sprague-DawleyCoated Materials, BiocompatibleHyaluronic AcidHydrogelsbiodegradationHADMherniahyaluronan coatinghyaluronidase

Identifiers

PMID30860665
PMCPMC6886263
OpenAlexW2922020321

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.