Trial reportAlcoholism, clinical and experimental research2019
The Interplay Between Subjective Response to Alcohol, Craving, and Alcohol Self-Administration in the Human Laboratory.
Trial report in Alcoholism, clinical and experimental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02026011 (Optimizing Naltrexone for Individuals of East Asian Descent), which is not on this map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Optimizing Naltrexone for Individuals of East Asian Descent
Who cites it
24 citing papers in PubMed, 26 citations in OpenAlex.
- Emotion regulation strategies moderate the impact of negative affect induction on alcohol craving in college drinkers: an experimental paradigm.Journal of American college health : J of ACH · 2023Trial
- Differential effects of UPPS-P impulsivity on subjective alcohol response and craving: An experimental test of acquired preparedness.Experimental and clinical psychopharmacology · 2023Trial
- The effect of neuroimmune modulation on subjective response to alcohol in the natural environment.Alcoholism, clinical and experimental research · 2022Trial
- Sex-Based Mechanisms of Stress-Induced Alcohol-Seeking.Behavioral sciences (Basel, Switzerland) · 2026Article
- Pharmacotherapy for Alcohol Craving Reduction: Efficacy of Short-Term Treatments in Alcohol Use Disorder.Medicines (Basel, Switzerland) · 2026Review
- Mechanisms explaining links between early-episode alcohol craving and subsequent drinking during naturally occurring drinking episodes.Psychopharmacology · 2026Article
- Influence of real-world cue exposure and mood states on drinking: testing neurobiological models of alcohol use disorder.Psychopharmacology · 2025Article
- The sequential daily process through which alcohol expectancies predict acute drinking behavior.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2025Article
- Are you feeling what I'm feeling? Momentary interactions between personal and perceived peer subjective response predict craving and continued drinking in young adults.Drug and alcohol dependence · 2025Article
- The Dopamine System in Mediating Alcohol Effects in Humans.Current topics in behavioral neurosciences · 2025Review
- Within-episode relations among simultaneous alcohol and cannabis use and continued drinking: The role of momentary subjective responses, craving, and drinking context.Alcohol, clinical & experimental research · 2024Article
- Modeling momentary reciprocal associations between negative affect and craving for alcohol and cannabis using dynamic structural equation modeling.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2024Article
- Pregaming potentiates risk between UPPS-P impulsivity and day-level drinking behavior: A test of person-environment transactions theory.Experimental and clinical psychopharmacology · 2024Article
- Changes in affect and alcohol craving during naturally occurring drinking episodes: The role of day-level drinking motives.Experimental and clinical psychopharmacology · 2023Article
- Disentangling between- and within-person alcohol and expectancy effects on acute alcohol craving.Psychopharmacology · 2023Article
- Alcohol craving in the natural environment: Moderating roles of cue exposure, drinking, and alcohol sensitivity.Experimental and clinical psychopharmacology · 2023Article
- Momentary subjective responses to alcohol as predictors of continuing to drink during daily-life drinking episodes.Drug and alcohol dependence · 2022Article
- Predicting Hypnotic Use among Insomnia Patients with the Theory of Planned Behavior and Craving.Behavioral sciences (Basel, Switzerland) · 2022Article
- Moderators of subjective response to alcohol in the human laboratory.Alcoholism, clinical and experimental research · 2022Article
- Craving, stimulation, and sedation as predictors of alcohol demand under intoxication.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDespite a rich literature on human laboratory paradigms of subjective response (SR) to alcohol, craving for alcohol, and alcohol self-administration, few studies have examined the interplay across these 3 constructs. The present study addresses this gap in the literature by examining the interplay between SR, craving, and self-administration in the human laboratory.
methodsData were culled from a medication study (NCT02026011) in which heavy drinking participants of East Asian ancestry completed 2 double-blinded and counterbalanced experimental sessions. In each experimental session, participants received a priming dose of intravenous (IV) alcohol to a target breath alcohol concentration (BrAC) of 0.06 g/dl and measures of SR (stimulation and sedation) and alcohol craving were collected across rising BrACs. The IV alcohol challenge was immediately followed by a 1-hour alcohol self-administration period.
resultsMixed model analyses found a positive and significant relationship between the slope of stimulation and the slope of craving during the alcohol challenge. The relationship between sedation and craving, however, was not significant. The slope of craving during the alcohol challenge significantly predicted a higher number of mini-drinks consumed and lower latency to first drink. Further, mediation analyses found that craving was a significant mediator of the relationship between stimulation and total number of mini-drinks consumed, but the same pattern was not found for sedation.
conclusionsInsofar as alcohol self-administration represents the end point of interest for a host of experimental and clinical research questions, the present study suggests that alcohol craving represents a more proximal predictor of self-administration than measures of alcohol-induced stimulation. It is recommended that human laboratory models interpret measures of SR and craving in light of their relative predictive utility for drinking outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.