ArticleThe Journal of comparative neurology2019
Variations in the proliferative activity of the peripheral retina correlate with postnatal ocular growth in squamate reptiles.
Article in The Journal of comparative neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 19 citations in OpenAlex.
- Neobaicalein Alleviates Retinal Damage via Microglia-Mediated Astrocyte Phenotypic Transformation.Applied biochemistry and biotechnology · 2025Article
- Cell-type expression and activation by light of neuropsins in the developing and matureFrontiers in cellular neuroscience · 2023Article
- Evaluation of the Potential Effects of Retinol and Alginate/Gelatin-Based Scaffolds on Differentiation Capacity of Mouse Mesenchymal Stem Cells (MSCs) into Retinal Cells.International journal of stem cells · 2022Article
- The developmental origins of heterodonty and acrodonty as revealed by reptile dentitions.Science advances · 2021Article
- Decline in Constitutive Proliferative Activity in the Zebrafish Retina with Ageing.International journal of molecular sciences · 2021Article
- Retinal Stem Cell 'Retirement Plans': Growth, Regulation and Species Adaptations in the Retinal Ciliary Marginal Zone.International journal of molecular sciences · 2021Review
- Development and postnatal neurogenesis in the retina: a comparison between altricial and precocial bird species.Neural regeneration research · 2021Article
- Loss of Active Neurogenesis in the Adult Shark Retina.Frontiers in cell and developmental biology · 2021Article
- Potential Endogenous Cell Sources for Retinal Regeneration in Vertebrates and Humans: Progenitor Traits and Specialization.Biomedicines · 2020Review
- Senescence in the pathogenesis of age-related macular degeneration.Cellular and molecular life sciences : CMLS · 2020Review
- Heterochronic Developmental Shifts Underlying Squamate Cerebellar Diversity Unveil the Key Features of Amniote Cerebellogenesis.Frontiers in cell and developmental biology · 2020Article
- Glia-Mediated Regenerative Response Following Acute Excitotoxic Damage in the Postnatal Squamate Retina.Frontiers in cell and developmental biology · 2020Article
- Comparative analysis of squamate brains unveils multi-level variation in cerebellar architecture associated with locomotor specialization.Nature communications · 2019Article
- Variations in the proliferative activity of the peripheral retina correlate with postnatal ocular growth in squamate reptiles.The Journal of comparative neurology · 2019Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The retina is a complex, multilayered tissue responsible for the perception of visual stimuli from the environment. Contrary to mammals, the capacity for postnatal eye growth in fish and amphibians, and to a lower extent in birds, is coordinated with a progenitor population residing in the ciliary marginal zone (CMZ) at the retinal peripheral margin. However, little is known about embryonic retinogenesis and postnatal retinal growth in squamates (lizards, snakes), despite their exceptional array of ecologies and ocular morphologies. Here, we address this gap by performing the first large-scale study assessing both ontogenetic and adult changes in the stem/progenitor activity of the squamate peripheral retina. Our study reveals for the first time that squamates exhibit a source of proliferating progenitors persisting post embryogenesis in a newly identified retinociliary junction anteriorly adjacent to the retina. This region is strikingly similar to the vertebrate CMZ by its peripheral location and pseudostratified nature, and shares a common pattern of slow-cycling cells, spatial differentiation gradient, and response to postnatal ocular growth. Additionally, its proliferative activity varies considerably among squamate species, in correlation with embryonic and postnatal differences in eye size and growth. Together our data indicate that squamates possess a proliferative peripheral retina that acts as a source of progenitors to compensate, at least in part, for postnatal ocular growth. Our findings also highlight the remarkable variation in activity and location of vertebrate retinal progenitors, indicating that the currently accepted scenario of reduced CMZ activity over the course of evolution is too simplistic.
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